Search Results:　 1-20 of 593

1

Pravastatin Inhibits Plaque Rupture and Subsequent Thrombus Formation in Atherosclerotic Rabbits with Hyperlipidemia

Wu Gang , Xie Qiang , Xu Lin 他

Chemical and pharmaceutical bulletin 61(2), 121-124, 2013-02-00
2

Change in Glucose Metabolism and Obesity in Pravastatin-treated Metabolic Syndrome Patients [in Japanese]

NAKAYA Noriaki , KAKU Miki , UEHARA Yoko , MATSUSHITA Yasuyuki , SAGAWA Kei , HIRAMATSU Katsutoshi

肥満研究 : 日本肥満学会誌 = Journal of Japan Society for the Study of Obesity 18(2), 106-117, 2012-08-25

Ichushi Web References (16)
3

Pravastatin Induces Placental Growth Factor (PGF) and Ameliorates Preeclampsia in a Mouse Model [in Japanese]

KUMASAWA Keiichi

Acta Obstetrica et Gynaecologica Japonica 64(8), 1865-1875, 2012-08-01

CiNii Fulltext PDF - Subscription Ichushi Web
4

Ezetimibe Improves Endothelial Function and Inhibits Rho-Kinase Activity Associated With Inhibition of Cholesterol Absorption in Humans

NOCHIOKA Kotaro , TANAKA Shin-ichi , MIURA Masanobu , ZHULANQIQIGE Do. e , FUKUMOTO Yoshihiro , SHIBA Nobuyuki , SHIMOKAWA Hiroaki

… mean age, 31±3 [SD] years-old) were randomized to receive ezetimibe (10mg/day) or pravastatin (10mg/day) for 4 weeks in a cross-over manner with a 4-week washout interval. … Although ezetimibe and pravastatin equally reduced low-density lipoprotein cholesterol (E: -25% vs. P: -21%), the CLR was reduced by ezetimibe but was rather increased by pravastatin (E: -41% vs. P: +37%; …

Circulation Journal 76(8), 2023-2030, 2012-07-25

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5

Intensity of Statin Therapy, Achieved Low-Density Lipoprotein Cholesterol Levels and Cardiovascular Outcomes in Japanese Patients After Coronary Revascularization : Perspectives From the CREDO-Kyoto Registry Cohort-2

NATSUAKI Masahiro , FURUKAWA Yutaka , MORIMOTO Takeshi , NAKAGAWA Yoshihisa , ONO Koh , KABURAGI Satoshi , INADA Tsukasa , MITSUOKA Hirokazu , TANIGUCHI Ryoji , NAKANO Akira , KITA Toru , SAKATA Ryuzo , KIMURA Takeshi

… standard statins [pravastatin, simvastatin, and fluvastatin]: 2,557 patients). …

Circulation Journal 76(6), 1369-1379, 2012-05-25

J-STAGE CrossRef References (33) Cited by (1)
6

Brief Overview and Application Examples of the EMP Rapidly-Disintegrating Tablets : Comparative Quality Evaluation of Pravastatin Sodium Tablets [in Japanese]

森田豊

製剤機械技術学会誌 = Journal of pharmaceutical machinery and engineering 21(4), 523-534, 2012-00-00
7

Pravastatin inhibits plaque rupture and subsequent thrombus formation in atherosclerotic rabbits with hyperlipidemia

Wu Gang , Xie Qiang , Xu Lin , Jiang Hong , Huang Zhengrong , Huang Congxin

… In order to explore the mechanism, we observed the effects of pravastatin on plaque stability in atherosclerotic rabbits. … Eight of them were administered with pravastatin (10 mg·kg-1·d-1) for 4 weeks. … Compared with model group, the thrombus area on aorta in pravastatin-treated group was reduced. … These results suggested that pravastatin could increase plaque stability and inhibit thrombosis through both lipid-dependent and lipid-independent way. …

Chemical and Pharmaceutical Bulletin, 2012

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8

Equivalence Studies of Pravastatin Original and Generic Drugs by Dissolution Test [in Japanese]

Nakauchi Takao , Takeuchi Ena , Okamoto Takuya , Teramoto Katsuya , Nozaki Aoi , Seko Fuko , Yuminoki Kayo , Katakawa Junichi , Hashimoto Naofumi

… We used the paddle method to perform dissolution tests on pravastatin sodium tablets (10 mg) to investigate the causes for these differences. … The pravastatin concentration was measured by UV spectroscopy and HPLC. … However, the percentage dissolved of pravastatin using JP1 decreased with time because pravastatin degraded in JP1. …

YAKUGAKU ZASSHI 132(8), 939-944, 2012

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9

Effects of Acidification and Alkalinization Agent on Statins-induced Muscle Toxicity [in Japanese]

Kobayashi Masaki , Hidaka Kazuhiro , Chisaki Ikumi , Takahashi Natsuko , Ogura Jiro , Itagaki Shirou , Hirano Takeshi , Yamaguchi Hiroaki , Iseki Ken

… CHC increased growth inhibition of RD cells induced by cerivastatin, a lipophilic statin, but not these induced by pravastatin, a hydrophilic statin. …

YAKUGAKU ZASSHI 132(5), 609-615, 2012

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10

Practical Application of Cytochrome P450

Sakaki Toshiyuki

… One of the most successful industrial applications of P450 may be the bioconversion process for pravastatin formation using a Streptomyces carbophilus CYP105A3. …

Biological and Pharmaceutical Bulletin 35(6), 844-849, 2012

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11

Effect of Intensive Lipid-Lowering Therapy With Rosuvastatin on Progression of Carotid Intima-Media Thickness in Japanese Patients : Justification for Atherosclerosis Regression Treatment (JART) Study

NOHARA Ryuji , DAIDA Hiroyuki , HATA Mitsumasa , KAKU Kohei , KAWAMORI Ryuzo , KISHIMOTO Junji , KURABAYASHI Masahiko , MASUDA Izuru , SAKUMA Ichiro , YAMAZAKI Tsutomu , YOKOI Hiroyoshi , YOSHIDA Wasayuki

… We conducted a prospective, randomized, open-label, blinded-endpoint trial to determine whether rosuvastatin is more effective than pravastatin in slowing progression of carotid IMT in Japanese patients. … Adult patients with hypercholesterolemia who had a maximum IMT ≥1.1mm were randomly assigned to receive rosuvastatin or pravastatin. … 175 pravastatin) were enrolled and 314 (159 rosuvastatin; … 155 pravastatin) were included in the primary analysis. …

Circulation Journal 76(1), 221-229, 2011-12-25

J-STAGE Ichushi Web CrossRef References (29) Cited by (2)
12

Acute Improvement by Pravastatin of Endothelial Function in Normolipidemic Males with Cardiovascular Risk Factors

TAKAHASHI Tomoko , IWASAKA Junji , HOKI Yae , HARADA Azusa , OISHI Chihiro , YOSHIOKA Kei , OTANI Hajime , IWASAKA Toshiji

日本臨床生理学会雑誌 = Japanese journal of applied physiology 41(4), 169-173, 2011-08-01

Ichushi Web References (21)
13

Lenalidomide in combination with dexamethasone induced rhabdomyolysis in a multiple myeloma patient treated with pravastatin

URATA Chisako , YOSHIMURA Mariko , ITAMURA Hidekazu , HISATOMI Takashi , KUBOTA Yasushi , FUKUSHIMA Noriyasu , SUEOKA Eisaburo , KIMURA Shinya

International journal of hematology 94(2), 216-217, 2011-08-01

References (8)
14

Comparison of Preventive Effect on Cardiovascular Events With Different Statins : The CIRCLE Study

MARUYAMA Takao , TAKADA Masanori , NISHIBORI Yoshiharu , FUJITA Kouichi , MIKI Koujirou , MASUDA Shigeki , HORIMATSU Tetsuo , HASUIKE Toshiaki

… Treatment with either atorvastatin or pitavastatin significantly reduced LDL-C compared with pravastatin or no statin. …

Circulation Journal 75(8), 1951-1959, 2011-07-25

J-STAGE Ichushi Web CrossRef References (34)
15

Cardioprotective Effects of Pravastatin Against Lethal Ventricular Arrhythmias Induced by Reperfusion in the Rat Heart

THUC Luong Cong , TESHIMA Yasushi , TAKAHASHI Naohiko , NISHIO Satoru , FUKUI Akira , KUME Osamu , EZAKI Kaori , MIYAZAKI Hiroko , YUFU Kunio , HARA Masahide , NAKAGAWA Mikiko , SAIKAWA Tetsunori

… Male rats were fed with or without pravastatin (0.1mg·kg<sup>-1</sup>·day<sup>-1</sup>) for 7 days, and thereafter subjected to 10min of ischemia by coronary artery ligation followed by 20min reperfusion. … Treatment with pravastatin reduced the frequency and duration of ventricular tachycardia and fibrillation (VT/VF) and improved the arrhythmia score after reperfusion. …

Circulation Journal 75(7), 1601-1608, 2011-06-25

J-STAGE Ichushi Web CrossRef References (30) Cited by (1)
16

Acute Modulation of Vasoconstrictor Responses by Pravastatin in Small Vessels

GHAFFARI Nader , BALL Christine , KENNEDY Jennifer A , STAFFORD Irene , BELTRAME John F

… We examined the effect of acute pravastatin pretreatment on vasoconstrictor responsiveness of isolated rat mesenteric small vessels. … Pravastatin (112nmol/L) pretreatment for 60min reduced both the potency and maximal constrictor responses to phenylephrine, thromboxane (U46619) and serotonin in small vessels. …

Circulation Journal 75(6), 1506-1514, 2011-05-25

J-STAGE Ichushi Web CrossRef References (49) Cited by (1)
17

Pitavastatin Increases ABCA1 Expression by Dual Mechanisms : SREBP2-Driven Transcriptional Activation and PPARα-Dependent Protein Stabilization but Without Activating LXR in Rat Hepatoma McARH7777 Cells

MAEJIMA Takashi , SUGANO Tomohiro , YAMAZAKI Hiroyuki , YOSHINAKA Yasunobu , DOI Takeshi , TANABE Sohei , NISHIMAKI MOGAMI Tomoko

… Pitavastatin, atorvastatin, and simvastatin increased total ABCA1 mRNA levels, whereas pravastatin had no effect. …

Journal of Pharmacological Sciences 116(1), 107-115, 2011-05-20

J-STAGE Ichushi Web CrossRef References (31)
18

Construction of a novel expression vector in Pseudonocardia autotrophica and its application to efficient biotransformation of compactin to pravastatin, a specific HMG-CoA reductase inhibitor

Fujii Yoshikazu , Norihisa Koji , Fujii Tadashi , Aritoku Yasuhide , Kagawa Yusuke , Sallam Khalid Ibrahim , Johdo Osamu , Arisawa Akira , Tamura Tomohiro

… autotrophica carrying pTAOR4 that harbors a compactin (CP)-hydroxylating P450 gene revealed 3.3-fold increased production of pravastatin (PV), a drug for hypercholesterolemia. …

Biochemical and Biophysical Research Communications 404(1), 511-516, 2011-01-07

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19

Brief Overview and Application Examples of the EMP Rapidly-Disintegrating Tablets : Comparative Quality Evaluation of Pravastatin Sodium Tablets [in Japanese]

森田豊

製剤機械技術学会誌 = Journal of pharmaceutical machinery and engineering 20(4), 421-433, 2011-00-00
20

Long-term Efficacy of Upstream Therapy With Lipophilic or Hydrophilic Statins on Antiarrhythmic Drugs in Patients With Paroxysmal Atrial Fibrillation Comparison Between Atorvastatin and Pravastatin:Comparison Between Atorvastatin and Pravastatin

Komatsu Takashi , Tachibana Hideaki , Sato Yoshihiro , Ozawa Mahito , Kunugita Fusanori , Nakamura Motoyuki

… We compared the efficacy and safety of atorvastatin (A-group, n = 43) and pravastatin (P-group, n = 41) as upstream therapy in patients with paroxysmal AF and dyslipidemia. … A total of 84 patients (45 men, mean age, 66 ± 9 years, mean follow-up, 49 ± 32 months) were retrospectively assigned to receive atorvastatin (n = 41;10 mg/day) or pravastatin (n = 43 ; …

International Heart Journal 52(6), 359-365, 2011

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