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Prilocaine Induces Apoptosis in Cultured Osteosarcoma Cells
[in Japanese]
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Nakamura Keiko
… To determine whether local anesthetics can induce apoptosis in osteoblastic cells, the effects of prilocaine were examined on cultured human osteoblastic cell lines, Saos-2 and MG63 cells, and mouse MC3T3-E1 cells. … The cells in confluence were exposed to varying concentrations of prilocaine. … In Saos-2 cells, prilocaine induced cell damage in a dose- and time-dependent manners up to the concentration of 10mM as determined by phase-contrast microscopy and WST-1 assay. …
The Journal of the Kyushu Dental Society 53(5), 639-650, 1999-10-25
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