検索結果 927件中 1-20 を表示

  • Carbon chain length of biofuel- and flavor-relevant volatile organic compounds produced by lignocellulolytic fungal endophytes changes with culture temperature

    Schoen Heidi R. , Hunt Kristopher A. , Strobel Gary A. , Peyton Brent M. , Carlson Ross P.

    Mycoscience : official journal of the Mycological Society of Japan 58(5), 338-343, 2017-09

  • Sirtuin A regulates secondary metabolite production by Aspergillus nidulans

    Itoh Eriko , Shigemoto Ryosuke , Oinuma Ken-Ichi , Shimizu Motoyuki , Masuo Shunsuke , Takaya Naoki

    … Late-stage cultures of filamentous fungi under nutrient starvation produce valuable secondary metabolites such as pharmaceuticals and pigments, as well as deleterious mycotoxins, all of which have remarkable structural diversity and wide-spectrum bioactivity. … The fungal mechanisms regulating the synthesis of many of these compounds are not fully understood, but sirtuin A (SirA) is a key factor that initiates production of the secondary metabolites, sterigmatocystin and penicillin G, by Aspergillus nidulans. …

    Journal of general and applied microbiology 63(4), 228-235, 2017-09

    機関リポジトリ DOI

  • 主解析とサブ解析 (特集 臨床研究の壺)

    関 直人

    内分泌・糖尿病・代謝内科 = Endocrinology, diabetology & metabolism 45(2), 110-114, 2017-08

  • Elucidation of the biosynthetic pathway of cis-jasmone in Lasiodiplodia theobromae

    Matsui Ryo , Amano Naruki , Takahashi Kosaku , Taguchi Yodai , Saburi Wataru , Mori Hideharu , Kondo Norio , Matsuda Kazuhiko , Matsuura Hideyuki

    In plants, cis-jasmone (CJ) is synthesized from a-linolenic acid (LA) via two biosynthetic pathways using jasmonic acid (JA) and iso-12-oxo-phytodienoic acid (iso-OPDA) as key intermediates. However, …

    Scientific reports 7(1), 6688, 2017-07-27

    機関リポジトリ DOI

  • Mechanism of Development of Atherosclerosis and Cardiovascular Disease in Diabetes Mellitus

    Katakami Naoto

    … <p>Diabetic macroangiopathy, atherosclerosis secondary to diabetes mellitus (DM), causes cerebro-cardiovascular diseases, which are major causes of death in patients with DM and significantly reduce their quality of life. …

    Journal of Atherosclerosis and Thrombosis, 2017

    DOI

  • 抗てんかん薬による血清脂質値の変化:脳梗塞患者での検討

    池田 憲

    <p>【目的】脳梗塞後てんかん患者でAED 単独療法による血清脂質値の変化を検討し,既報告を概説した.【方法】急性期脳梗塞患者でvalproate(VA),carbamazepine(CBZ),phenytoin(PHT), zonisamide(ZNS),levetiracetam(LEV),lamotrigine(LTG)を単剤で開始した133 名とした.血清脂質値はAED 服用前 …

    脳卒中 39(5), 400-404, 2017

    DOI

  • Circulating ANGPTL2 Levels Increase in Humans and Mice Exhibiting Cardiac Dysfunction

    Tian Zhe , Miyata Keishi , Morinaga Jun , Horiguchi Haruki , Kadomatsu Tsuyoshi , Endo Motoyoshi , Zhao Jiabin , Zhu Shunshun , Sugizaki Taichi , Sato Michio , Terada Kazutoyo , Okumura Takahiro , Murohara Toyoaki , Oike Yuichi

    … <p><b><i>Background:</i></b>Recently, it was reported that angiopoietin-like protein 2 (ANGPTL2) secreted from a pathologically stressed heart accelerates cardiac dysfunction in an autocrine/paracrine manner, and that suppression of ANGPTL2 production in the heart restored cardiac function and myocardial energy metabolism, thereby blocking heart failure (HF) development. …

    Circulation Journal, 2017

    DOI

  • Sirtuin A regulates secondary metabolite production by <i>Aspergillus nidulans</i>

    Itoh Eriko , Shigemoto Ryosuke , Oinuma Ken-Ichi , Shimizu Motoyuki , Masuo Shunsuke , Takaya Naoki

    … <p>Late-stage cultures of filamentous fungi under nutrient starvation produce valuable secondary metabolites such as pharmaceuticals and pigments, as well as deleterious mycotoxins, all of which have remarkable structural diversity and wide-spectrum bioactivity. …

    The Journal of General and Applied Microbiology 63(4), 228-235, 2017

    DOI

  • Hypertension is a characteristic complication of X-linked hypophosphatemia

    Nakamura Yoshie , Takagi Masaki , Takeda Ryojun , Miyai Kentaro , Hasegawa Yukihiro

    Secondary hyperparathyroidism preceded the development of hypertension in 5 patients. …

    Endocrine Journal 64(3), 283-289, 2017

    DOI

  • Critical Care Management Focused on Optimizing Brain Function After Cardiac Arrest

    Nakashima Ryuta , Hifumi Toru , Kawakita Kenya , Okazaki Tomoya , Egawa Satoshi , Inoue Akihiko , Seo Ryutaro , Inagaki Nobuhiro , Kuroda Yasuhiro

    … There has been less attention paid to target values for systemic and cerebral parameters to minimize secondary brain damage in PCAS. … Issues are (1) prediction of TTM candidate on admission, (2) cerebral blood flow and metabolism and target value of them, (3) seizure management using continuous electroencephalography, (4) target value of hemodynamic stabilization and its method, (5) management and analysis of respiration, (6) sedation and its monitoring, (7) shivering control and its monitoring, and (8) glucose management. …

    Circulation Journal 81(4), 427-439, 2017

    DOI

  • Serum levels of ochratoxin A in dogs with chronic kidney disease (CKD): a retrospective study

    MEUCCI Valentina , LUCI Giacomo , VANNI Michele , GUIDI Grazia , PERONDI Francesca , INTORRE Luigi

    … <p>Ochratoxin A (OTA) is a mycotoxin produced by secondary metabolism of several fungi belonging to the genera <i>Aspergillus</i> …

    The Journal of Veterinary Medical Science 79(2), 440-447, 2017

    DOI

  • Comparative analysis of the effects of alogliptin and vildagliptin on glucose metabolism in type 2 diabetes mellitus

    Tanaka Kenichi , Okada Yosuke , Mori Hiroko , Miyazaki Megumi , Kuno Fumi , Sonoda Satomi , Sugai Kei , Hajime Maiko , Kurozumi Akira , Narisawa Manabu , Torimoto Keiichi , Arao Tadashi , Mine Shinichiro , Tanaka Yoshiya

    … The aim of this 24-week, prospective randomized open-label study was to compare the effects of alogliptin and vildagliptin on glucose control, renal function, and lipid metabolism. … The primary endpoint was change in glycosylated hemoglobin (HbA1c) level at 24 weeks, while the secondary endpoints were changes in urinary albumin excretion and low-density lipoprotein cholesterol (LDL-C) levels at 24 weeks. …

    Endocrine Journal 64(2), 179-189, 2017

    DOI

  • Critical Care Management Focused on Optimizing Brain Function After Cardiac Arrest

    Nakashima Ryuta , Hifumi Toru , Kawakita Kenya , Okazaki Tomoya , Egawa Satoshi , Inoue Akihiko , Seo Ryutaro , Inagaki Nobuhiro , Kuroda Yasuhiro

    … There has been less attention paid to target values for systemic and cerebral parameters to minimize secondary brain damage in PCAS. … Issues are (1) prediction of TTM candidate on admission, (2) cerebral blood flow and metabolism and target value of them, (3) seizure management using continuous electroencephalography, (4) target value of hemodynamic stabilization and its method, (5) management and analysis of respiration, (6) sedation and its monitoring, (7) shivering control and its monitoring, and (8) glucose management. …

    Circulation Journal, 2017

    DOI

  • Diurnal Transcriptional Regulation of Endosymbiotically Derived Genes in the Chlorarachniophyte Bigelowiella natans

    Suzuki Shigekatsu , Ishida Ken-Ichiro , Hirakawa Yoshihisa

    … Chlorarachniophyte algae possess complex plastids acquired by the secondary endosymbiosis of a green alga, and the plastids harbor a relict nucleus of the endosymbiont, the so-called nucleomorph. … Clustering analysis of those genes revealed the existence of transcriptional networks related to specific biological processes such as photosynthesis, carbon metabolism, translation, and DNA replication. …

    Genome biology and evolution 8(9), 2672-2682, 2016-09

    機関リポジトリ DOI

  • Combination of soya pulp and Bacillus coagulans lilac-01 improves intestinal bile acid metabolism without impairing the effects of prebiotics in rats fed a cholic acid-supplemented diet

    Lee Yeonmi , Yoshitsugu Reika , Kikuchi Keidai , Joe Ga-Hyun , Tsuji Misaki , Nose Takuma , Shimizu Hidehisa , Hara Hiroshi , Minamida Kimiko , Miwa Kazunori , Ishizuka Satoshi

    … Intestinal bacteria are involved in bile acid (BA) deconjugation and/ or dehydroxylation and are responsible for the production of secondary BA. … However, an increase in the production of secondary BA modulates the intestinal microbiota due to the bactericidal effects and promotes cancer risk in the liver and colon. …

    British journal of nutrition 116(4), 603-610, 2016-08

    機関リポジトリ DOI

  • 複合培養による放線菌抗生物質生産の覚醒 (特集 共培養による"ものづくり"の発展)

    尾仲 宏康

    Bio industry = バイオインダストリー 33(3), 4-10, 2016-03

  • 放線菌における抗生物質ホルミシス効果による二次代謝活性化

    保坂 毅 , 今井 優

    バイオサイエンスとインダストリー 74(6), 516-518, 2016

    医中誌Web

  • 3.二次性高血圧の最前線~原発性アルドステロン症を中心に~

    小川 佳宏 , 吉本 貴宣

    日本内科学会雑誌 105(3), 434-438, 2016

    医中誌Web DOI

  • Somatostatin-secreting Pheochromocytoma Mimicking Insulin-dependent Diabetes Mellitus

    Hirai Hiroyuki , Midorikawa Sanae , Suzuki Shinichi , Sasano Hironobu , Watanabe Tsuyoshi , Satoh Hiroaki

    <p>We herein present the findings of a 42-year-old woman with either adrenal pheochromocytoma or intraadrenal paraganglioma that simultaneously secreted somatostatin, thus mimicking insulin-depe …

    Internal Medicine 55(20), 2985-2991, 2016

    医中誌Web DOI

  • 硬化性胆管炎の治療と予後

    田妻 進 , 菅野 啓司 , 芹川 正浩

    <p>硬化性胆管炎は主に原発性硬化性胆管炎(PSC),IgG4関連硬化性胆管炎(IgG4-SC),二次性硬化性胆管炎(SSC)に分類される.PSCの根本的治療は現時点では肝移植しかないが,内視鏡治療は減黄や胆道感染のコントロールにより移植までの期間を延長することや,肝移植不能例における肝不全への進行を遅らせる役割を果たす.薬物治療としてはウルソデオキシコール酸(UDCA)が第一選択薬と …

    胆道 30(5), 911-916, 2016

    医中誌Web DOI

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