検索結果:　 933件中 1-20 を表示

1

Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines

Haniu Hisao , Saito Naoto , Matsuda Yoshikazu , Kim Yoong-Ahm , Park Ki Chul , Tsukahara Tamotsu , Usui Yuki , Aoki Kaoru , Shimizu Masayuki , Ogihara Nobuhide , Hara Kazuo , Takanashi Seiji , Okamoto Masanori , Ishigaki Norio , Nakamura Koichi , Kato Hiroyuki

… Carbon blacks were endocytosed by the same cell types without lysosomal damage and caused cytokine secretion, but they did not cause cytotoxicity. … Furthermore, it seems that membrane permeability or cytokine secretion without cytotoxicity results from several active mechanisms. … Clarification of the cellular recognition mechanism for MWCNTs is important for developing safer MWCNTs. …

International Journal of Nanomedicine 1(6), 3487-3497, 2011-12-21

機関リポジトリ CrossRef
2

ヒトの生理的状態下および病態下における体内ビタミンE量の代謝的調節機構に関する研究

玉井浩

… Another major mechanism to regulate vitamin E status in the serum is the metabolism of excessive α-tocopherol to α-CEHC (2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydrochroman) in the liver and the resulting α-CEHC is secreted into the urine. … A large part of γ-tocopherol administered to humans at a large dose is also metabolized to γ-CEHC in the liver and the resulting γ-CEHC stimulates the secretion of sodium to the urine in the kidney. …

ビタミン 85(9), 463-470, 2011-09-25

CiNii PDF - 未公開医中誌
3

Por Secretion System of Porphyromonas gingivalis

Sato Keiko

… gingivalis does not have genes homologous to those coding these secretion systems in the bacterial genome and not much is known about the mechanism of gingipain secretion. … In this study, the proteins responsible for gingipain secretion, i.e., PorK, PorL, PorM, PorN, and PorW, were identified by comparative genome analysis and genetic experiments. …

Journal of Oral Biosciences 53(3), 187-196, 2011-09-06

機関リポジトリ
4

Diverse molecular forms of plasma B-type natriuretic peptide in heart failure.

Nishikimi Toshio , Minamino Naoto , Nakao Kazuwa

… In the future, the precise mechanism of increased proBNP-108 in HF should be elucidated. …

Current heart failure reports 8(2), 140-146, 2011-06

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5

Molecular mechanism of impaired metabolism-secretion coupling in diabetic pancreatic β cells

Fujimoto Shimpei

Diabetology international 2(3), 122-126, 2011
6

気道の水分泌制御機構

丸中良典 , 新里直美

呼吸と循環 59(9), 911-918, 2011-09

医中誌
7

唾液分泌のメカニズム (2009年度口腔四学会合同研修会 (社)日本口腔外科学会第33・34回教育研修会唾液腺疾患--その基礎から臨床まで)

杉谷博士

日本口腔外科学会雑誌 57(4), 182-186, 2011-04

医中誌
8

インクレチンのインスリン分泌促進作用の分子メカニズム (特集インクレチン関連薬--糖尿病治療のパラダイムシフト) -- (インクレチンの基礎・臨床研究の進歩)

藤田征弘 , 羽田勝計

日本臨床 69(5), 808-812, 2011-05

医中誌
9

インクレチンの分泌調節機構 (特集インクレチン関連薬--糖尿病治療のパラダイムシフト) -- (インクレチンの基礎・臨床研究の進歩)

柴崎忠雄 , 清野進

日本臨床 69(5), 803-807, 2011-05

医中誌
10

Artemisia afra Jacq. Ameliorates Oxidative Stress in the Pancreas of Streptozotocin-Induced Diabetic Wistar Rats

AFOLAYAN Anthony Jide , SUNMONU Taofik Olatunde

… Diabetes is characterized by hyperglycemia resulting from defects in pancreatic insulin secretion and/or impaired target cell responsiveness to insulin, and Artemisia afra Jacq. … is widely used in South Africa to treat the disease, but the mechanism of action is yet to be elucidated. …

Bioscience, Biotechnology, and Biochemistry 75(11), 2083-2086, 2011

J-STAGE CrossRef
11

食品因子の腸管吸収および生理機能の分子栄養学的研究 : (平成22年度日本栄養・食糧学会奨励賞受賞)

薩秀夫

本研究では食品因子の腸管上皮透過機構および腸管上皮細胞機能に対する生理作用を主に細胞レベルで解析した。食品因子はトランスポーターや細胞間隙経路など様々な経路を介して腸管上皮細胞層を透過すること, 一方で腸管上皮トランスポーター活性は他の食品因子によって制御されることが見出された。また腸管上皮モデルCaco-2細胞と活性化マクロファージモデルTHP-1細胞との複合培養系を用いて, 抗腸炎症作用を有す …

日本栄養・食糧学会誌 64(4), 207-214, 2011

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12

The role of sulfoglucuronosyl glycosphingolipids in the pathogenesis of monoclonal IgM paraproteinemia and peripheral neuropathy

ARIGA Toshio

… In IgM paraproteinemia and peripheral neuropathy, IgM M-protein secretion by B cells leads to a T helper cell response, suggesting that it is antibody-mediated autoimmune disease involving carbohydrate epitopes in myelin sheaths. … These animal models might help to understand the disease mechanism and lead to more specific therapeutic strategies. …

Proceedings of the Japan Academy, Series B 87(7), 386-404, 2011

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13

Induction of Differentiation by Panaxydol in Human Hepatocarcinoma SMMC-7721 Cells via cAMP and MAP Kinase Dependent Mechanism

WANG Ze-Jian , SONG Li , GUO Lin-Chen , YIN Min , SUN Yong Ning

… Moreover, panaxydol dose-dependently increased the secretion of albumin and alkaline phosphatase activity, and decreased the secretion of AFP correspondingly. … It suggested panaxydol might be of value for further exploration as a potential anti-cancer agent via cAMP and MAP kinase-dependent mechanism. …

YAKUGAKU ZASSHI 131(6), 993-1000, 2011

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14

Increased Lipid Accumulation in Liver and White Adipose Tissue in Aging in the SAMP10 Mouse

HONMA Taro , YANAKA Miyuki , TSUDUKI Tsuyoshi , IKEDA Ikuo

… To examine this mechanism in detail, aging-related changes in mRNA expression of genes related to lipid and carbohydrate metabolism were examined by DNA microarray analysis. … The mRNA level for Hsd11b1 (hydroxysteroid 11-beta dehydrogenase 1), which increases insulin secretion and resistance, was elevated with aging in the liver of SAMP10 mice. …

Journal of Nutritional Science and Vitaminology 57(2), 123-129, 2011

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15

Rhapontigenin Inhibited Hypoxia Inducible Factor 1 Alpha Accumulation and Angiogenesis in Hypoxic PC-3 Prostate Cancer Cells

Jung Deok-Beom , Lee Hyo-Jeong , Jeong Soo-Jin , Lee Hyo-Jung , Lee Eun-Ok , Kim Young Chul , Ahn Kyoo Seok , Chen Chang-Yan , Kim Sung-Hoon

… In the present study, the inhibitory mechanism of rhapontigenin isolated from Vitis coignetiae was investigated on HIF-1α stability and angiogenesis in human prostate cancer PC-3 cells. … Furthermore, rhapontigenin reduced vascular endothelial growth factor (VEGF) secretion in hypoxic PC-3 cells as well as suppressed tube formation in human umbilical vein endothelial cells (HUVECs) treated by the conditioned media of hypoxic PC-3 cells. …

Biological & Pharmaceutical Bulletin 34(6), 850-855, 2011

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16

Function of K+–Cl− Cotransporters in the Acid Secretory Mechanism of Gastric Parietal Cells

Fujii Takuto , Fujita Kyosuke , Takeguchi Noriaki , Sakai Hideki

… For the HCl secretion, Cl−- and K+-transporting proteins are required. … This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells. …

Biological & Pharmaceutical Bulletin 34(6), 810-812, 2011

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17

Immunohistochemical and Histoplanimetrical Study on the Spatial Relationship between the Settlement of Indigenous Bacteria and the Secretion of Bactericidal Peptides in Rat Alimentary Tract

YOKOO Yuh , MIYATA Hidenori , UDAYANGA Kankanam Gamage Sanath , QI Wang-Mei , TAKAHARA Ei-ichirou , MANTANI Youhei , YOKOYAMA Toshifumi , KAWANO Junichi , HOSHI Nobuhiko , KITAGAWA Hiroshi

… To clarify the regulatory mechanism by bactericidal peptides secretion, the secretion of bactericidal peptides was immunohistochemically and histoplanimetrically compared with the degree of Gram-positive/negative bacterial colonization throughout the rat alimentary tract. …

Journal of Veterinary Medical Science advpub(0), 1104200494, 2011

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18

Novel Situations of Endothelial Injury in Stroke — Mechanisms of Stroke and Strategy of Drug Development: Novel Mechanism of the Expression and Amplification of Cell Surface–Associated Fibrinolytic Activity Demonstrated by Real-Time Imaging Analysis

Suzuki Yuko , Urano Tetsumei

… Vascular endothelial cells (VECs) secrete tissue plasminogen activator (tPA) in an active form and thus its facilitated secretion directly enhances fibrinolytic activity. … tPA-GFP appeared to remain on the cell surface after secretion. …

Journal of Pharmacological Sciences 116(1), 19-24, 2011

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19

The Mechanism Underlying the Synergetic Hypocholesterolemic Effect of Sesamin and α-Tocopherol in Rats Fed a High-Cholesterol Diet

Rogi Tomohiro , Tomimori Namino , Ono Yoshiko , Kiso Yoshinobu

… To elucidate the molecular mechanism behind this effect, we analyzed the gene-expression profiles in rat liver after co-ingestion of sesamin and α-tocopherol. … ApoA4 controls the secretion of ApoB, which is a component of low-density-lipoprotein cholesterol. …

Journal of Pharmacological Sciences 115(3), 408-416, 2011

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20

Nateglinide Stimulates Glucagon-Like Peptide-1 Release by Human Intestinal L Cells via a KATP Channel-Independent Mechanism

Kitahara Yoshiro , Miura Kyoko , Yasuda Reiko , Kawanabe Haruka , Ogawa Shimpei , Eto Yuzuru

… In addition, the major metabolite of nateglinide, tolbutamide, and mitiglinide, all of which augment insulin secretion by the pancreatic islets, had no effect on GLP-1 release by this cell line. … Taken together, the present findings indicate that promotion of GLP-1 release from intestinal L cells may be another important mechanism by which nateglinide restores early-phase insulin secretion and regulates postprandial glucose metabolism. …

Biological & Pharmaceutical Bulletin 34(5), 671-676, 2011

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