検索結果:　3840件中 1-20 を表示

Tanaka Mari , Asada Misako , Higashi Atsuko Y. , Nakamura Jin , Oguchi Akiko , Tomita Mayumi , Yamada Sachiko , Asada Nariaki , Takase Masayuki , Okuda Tomohiko , Kawachi Hiroshi , Economides Aris N. , Robertson Elizabeth , Takahashi Satoru , Sakurai Takeshi , Goldschmeding Roel , Muso Eri , Fukatsu Atsushi , Kita Toru , Yanagita Motoko , 柳田 素子

… Previously, we have demonstrated that the bone morphogenetic protein (BMP) antagonist uterine sensitization–associated gene-1(USAG-1) negatively regulates the renoprotective action of BMP-7 in a mouse model of tubular injury during acute renal failure. …

Journal of Clinical Investigation, 2010-02-08

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Takahashi Go , Tanaka Hiroyuki , Wakahara Keiko , Nasu Reishi , Hashimoto Mikiko , Miyoshi Kosuke , Takano Hirohisa , Yamashita Hirotaka , Inagaki Naoki , Nagai Hiroichi

… with Der f 4 times throughout the experiment or twice at the sensitization period. … These findings indicate that DEP can potentiate airway remodeling induced by repeated allergen challenge as well as Th2-drived airway hyperresponsiveness, eosinophilic inflammation, and IgG1 production and that DEP can exhibit adjuvant activity for airway remodeling, probably due to the enhancement of allergen sensitization and/or of Th2 polarizing pathways. …

Journal of Pharmacological Sciences advpub(0), 1001190331, 2010

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宮川 宗之

… Although the GHS provides definitions and classification criteria for 10 classes of health hazards (acute toxicity, skin and eye corrosion/irritation, sensitization, germ cell mutagenicity, carcinogenicity, reproductive toxicity, specific target organ toxicity single/repeated exposures, and aspiration hazard), it does not provide actual classification of chemicals, so that competent authorities and industries need to classify a number of chemicals and/or mixtures. …

日本衛生学雑誌 65(1), 5-13, 2010

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SUGURO Mayuko , MATSUYAMA Hayato , TANAHASHI Yasuyuki , UNNO Toshihiro , KITAZAWA Takio , YAMADA Masahisa , KOMORI Seiichi

… In the present study, we have characterized muscarinic receptor subtypes that mediate carbachol-induced Ca2+ sensitization of contraction in intestinal smooth muscle, using mutant mice lacking M2 or M3 muscarinic receptors or both receptor subtypes. … The Gq/11-type G-protein inhibitor YM-254890 (1 μM) completely blocked the Ca2+ sensitization of contraction induced by carbachol in M2-KO or WT preparations. …

Journal of Veterinary Medical Science advpub(0), 0912040085, 2010

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SATO Kazuhiro , UMEMURA Tomohiro , TAMURA Tarou , KUSAKA Yukinori

… In silico assessment of skin sensitization is increasingly needed owing to the problems concerning animal welfare, as well as excessive time consumed and cost involved in the development and testing of new chemicals. … Skin sensitization positive/negative prediction models with discriminant function were generated and parameter analysis was discussed on the basis of QSAR technology. … This is the first QSAR model for skin sensitization from Japan. …

Alternatives to Animal Testing and Experimentation 14(3), 940-946, 2009-12

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Komura Kazuhiro , Yanaba Koichi , Horikawa Mayuka , Ogawa Fumihide , Fujimoto Manabu , Tedder Thomas F. , Sato Shinichi , 小村 一浩 , 藤本 学

… Although LZT resulted from the inhibition of the sensitization phase, the effects on the effector/elicitation phase remain unknown. … Thus, ICAM-1 deficiency did not affect sensitization. …

Journal of Investigative Dermatology 129(11), 2661-2667, 2009-11

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増子 佳世

日本臨床 67(9), (962) 1741〜1747, 2009/9

医中誌