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1

Optimized Preparation, Characterization and Biodistribution in Heart of Breviscapine Lipid Emulsion

Xiong Fei , Wang Hao , Geng Kun-kun , Gu Ning , Zhu Jia-bi

… The use of a lipid emulsion formulation containing breviscapine might improve chemical stability, increase drug loading, exhibit sustained release profile. … In the present study, we developed an optimized formulation and technological method for the preparation of sterile and stable breviscapine lipid emulsion (Bre-LE) for intravenous infusion. …

Chemical and Pharmaceutical Bulletin 58(11), 1455-1460, 2010

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2

REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (2) : COMBINED STUDY OF EFFECTS ON FERTILITY AND EMBRYO-FETAL TOXICITY IN FEMALE RATS BY INTRAVENOUS ADMINISTRATION [in Japanese]

KAWAGUCHI Takashi , SAGAMI Fumio , TIRONE Piero , MORISETTI Alberto , BUSSI Simona , BAGULEY Jane K.

受胎能および胚・胎児発生に及ぼすガドベン酸ジメグルミン製剤(E7155)の影響について雌性SDラットを用いて検討した。一群22匹の雌性ラットに0.3,1.0または2.0mmol/kg/日のE7155を交配前15日間,静脈内投与を行った。投与は交配中も継続し,妊娠17日まで投与を行った。対照動物には同じ期間中0.9%滅菌生理食塩液を投与した。妊娠20日にすべての雌動物を屠殺し,子宮内容物の検査を行っ …

Journal of toxicological sciences 24(SupplementI), 71-78, 1999-11-15

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3

REPRODUCTIVE AND DEVELOPMENTAL TOXICITY STUDY OF GADOBENATE DIMEGLUMINE FORMULATION (E7155) (1) : FERTILITY STUDY IN MALE RATS BY INTRAVENOUS ADMINISTRATION [in Japanese]

OKADA Fumihiro , SAGAMI Fumio , TIRONE Piero , MORISETTI Alberto , BUSSI Simona , BAGULEY Jane K.

雄性SDラットにガドベン酸ジメグルミン製剤(E7155)を投与した際の生殖能および授胎能に及ぼす影響について検討した。一群22匹の雄性ラットにE7155の0.3,1.0または2.0mmol/kg/日を13週間静脈内投与した。対照動物には同じ期間中0.9%滅菌生理食塩液を尾静脈内に投与した。4週間の投与後,各雄動物と同系統の無処置雌動物を同居させた。10週間の投与後,再度各雄動物と同系統の別の無処 …

Journal of toxicological sciences 24(SupplementI), 61-69, 1999-11-15

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4

Stabilization of Octastation, a Somatostatin Analogue. Preparation of Freeze-Dried Products for Parenteral Injection

POURRAT Henri , BARTHOMEUF Chantal , POURRAT Aimee , COTTIER Pierre-Edouard , IBRAHIM Houssam

… Various freeze-drying conditions, stabilizing agents, membranes for sterile filtration and heating procedures have been examined. … The formulation with glutamic acid-sodium glutamate buffer as a stabilizing agent, the type of membrane for filtration and the freeze-drying procedure have been found appropriate for subsequent industrial production. …

Biological & pharmaceutical bulletin 18(5), 766-771, 1995-05-15

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5

Theoretical Consideration of Heat Sterilization Kinetics : Kinetic Studies on the Thermal Death Rate of Microorganisms…I [in Japanese]

Terui Gyozo

… In the historical system, the sensitivity is affected by heat to which spores (or survivors) have been exposed.(II) Formulation of the thoretical thermal death time (TDT) in the case of the nonhistrical system of single-hit type.Thermal death rate constant is regarded as the probability density of the event (thermal death), that is the probability per cell per unit time; …

Journal of fermentation technology. 44(8), 534-542, 1966-08-25

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