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LUAN Jiajie , LI Weiping , HAN Jia , ZHANG Wen , GONG Huiling , MA Rong

… The present study was carried out to investigate the protective effects of tempol on renal function and the underlying mechanism in streptozotocin-induced diabetic rats. … In addition, diabetes decreased activities of SOD and GSH-Px and these responses were prevented by tempol treatment. …

Journal of Pharmacological Sciences 119(2), 167-176, 2012-06-20

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FENG Xiao-Tao , QIN Can-Bin , LENG Jing , TANG Qian-Li , SHI Hong , ZHAI Lin-Na , LI Shuang-Lei

… Moreover, streptozotocin-induced diabetes severely impaired rats' erectile function and the activity of the NO-cGMP pathway in the corpora cavernosum, and treatment with Yidiyin for 4 weeks obviously increased the rats' erectile function, remarkably enhanced the activity of nitric oxide synthase (NOS), and elevated the contents of NO and cGMP. …

Bioscience, Biotechnology, and Biochemistry 76(2), 257-263, 2012-02-23

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IMAI Eri , SANO Mitsue , FUKUWATARI Tsutomu , SHIBATA Katsumi

… To investigate this hypothesis, diabetes was induced in male Wistar rats (6 wk old) by streptozotocin treatment, and they were then given diets containing low, medium or sufficient vitamins for 70 d. … The blood concentrations of vitamin B12 and folate were lowered by diabetes, while, those of vitamin B1, vitamin B2, vitamin B6, and biotin were not. …

Journal of Nutritional Science and Vitaminology 58(1), 54-58, 2012

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Yamada Kumi , Niki Hisae , Nagai Hitoshi , Nishikawa Masakuni , Nakagawa Haruto

… To clarify the involvement of 5-hydroxytryptamine (5-HT) in promotion of thrombogenesis in diabetes, we examined the inhibitory effect of sarpogrelate, a 5-HT<SUB>2A</SUB> … In streptozotocin-induced diabetic rats, polyethylene tube–induced thrombus formation was enhanced compared with that in normal rats. … Sarpogrelate but not aspirin inhibited the increase in VCAM-1 expression induced by high glucose and 5-HT. …

Journal of Pharmacological Sciences 119(3), 243-250, 2012

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Kawakubo Ken , Mori Asami , Sakamoto Kenji , Nakahara Tsutomu , Ishii Kunio

… We examined the effects of GP-1447 (3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]-5-methylphenyl acetic acid) on existing cataracts and sorbitol content in the lens in rats with streptozotocin-induced diabetes. … Cataracts in the central region of the lens were observed in 7 of 14 eyes (50%) by the fifth week after induction of diabetes, and development of mature cataracts was observed in most lenses by the ninth week. …

Biological and Pharmaceutical Bulletin 35(6), 866-872, 2012

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Al-Hashem Fahaid , Ibrahim Ibrahim , Bastawy Nermeen , Rateb Moshira , Haidara Mohamed , Dallak Mohammed , Soskic Sanja , Bin-Jaliah Ismaeel , Isenovic Esma

… The present study was designed to investigate the effect of insulin on insulin resistance (IR), plasma adiponectin level and expression of adiponectin receptors 1 (AdipoR1) in obese and streptozotocin-induced type 2 diabetic rats. … Type 2 diabetic mellitus was induced in the 3rd and 4th experimental groups by given 30 mg/kg of a single dose streptozotocin via intraperitoneal injection (i.p.). …

JOURNAL OF HEALTH SCIENCE 57(4), 334-340, 2011

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Nawa Ayaka , Fujita-Hamabe Wakako , Tokuyama Shogo

… Our previous study clearly revealed that intestinal P-gp expression levels were decreased via an inducible nitric oxide synthase (iNOS)-mediated mechanism in the early phases of diabetes. … Here, we focused on changes in ileal P-gp expression and the influences of NOS on the P-gp expression levels in the later phase of diabetic condition using streptozotocin (STZ)-induced diabetic mice. …

Biological and Pharmaceutical Bulletin 34(3), 436-438, 2011

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SHEN Yan , FUKUSHIMA Misato , ITO Yoshimasa , MURAKI Etsuko , HOSONO Takashi , SEKI Taiichiro , ARIGA Toyohiko

… Streptozotocin-induced diabetic rats were divided into four groups and orally administered with an aqueous cinnamon extract (CE) for 22 d. …

Bioscience, Biotechnology, and Biochemistry 74(12), 2418-2425, 2010-12-23

J-STAGE Ichushi Web CrossRef References (37)

INADA Akari , INADA Oogi , FUJII Hiroshi , AKASHI Tomoyuki , SUEISHI Katsuo , FUKATSU Atsushi , NAGAFUCHI Seiho

Diabetology international 1(1), 49-59, 2010-11-01

References (58)