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Synthesis of Imidazo [4,5-e]-as-triazine (6-Azapurine) Derivatives
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KAJI KENJI
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KAWASE MASAMI
… Selective thionation of these amino derivatives (IIa, b), by heating with phosphorus pentasulphide in pyridine, to lead to 6-amino-(IIIa) and 6-benzylamino-2-benzyl-as-triazin-3 (2H)-one-5 (4H)-thione (IIIb), effectively proceeded, and subsequent aminodethiolation of the latter (IIIa, b) also readily went on to afford 5,6-diamino-(IVa), 5-amino-6-benzylamino-(IVb), 5-benzylamino-6-amino-(IVc), and 5,6-dibenzylamino-2-benzyl-as-triazin-3 (2H)-one (IVd). …
Chemical & pharmaceutical bulletin 24(9), 2274-2277, 1976-09-25
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