CiNii Articles - thromboxane A_2 synthetase inhibitor

1

Effect of a selective thromboxane A_2 synthetase inhibitor on the systemic changes induced by circulating pancreatic phospholipase A_2

MOTOYOSHI MAKOTO , SUGIYAMA MASANORI , ATOMI YUTAKA , KIMURA WATARU , NAGAWA HIROKAZU

Journal of gastroenterology 41(11), 1094-1098, 2006-11-01

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2

A Novel Series of Thromboxane A_2 Synthetase Inhibitors with Free Radical Scavenging and Anti-peroxidative Activities

KAMIYA Shoji , SHIRAHASE Hiroaki , NAKAMURA Shohei , KANDA Mamoru , MATSUI Hiroshi , YOSHIMI Akihisa , KASAI Masayasu , TAKAHASHI Kenji , KURAHASHI Kazuyoshi

… A novel series of indoline derivatives with imidazole and carboxyl moieties were synthesized and evaluated for their thromboxane A_2(TXA_2)synthetase inhibiting, radical scavenging and anti-peroxidative activities. …

Chemical & pharmaceutical bulletin 49(5), 563-571, 2001-05-01

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3

In vitro effects of E3040, a dual inhibitor of 5-lipoxygenase and thromboxane A_2 synthetase, on eicosanoid production

OKETANI K

Eur J Pharmacol. 422, 209-216, 2001

Cited by (2)
4

Percutaneous Penetration of Ozagrel and the Enhancement Produced by Saturated Fatty Acids

OGISO Taro , KOIKE Kazunori , IWAKI Masahiro , TANINO Tadatoshi , TANABE Genzou , MURAOKA Osamu

… The effects of a series of fatty acids on the percutaneous penetration of ozagrel (OZ), a selective thromboxane A_2 synthetase inhibitor, through rat skin and the mechanism by which fatty acids enhance the skin penetration of OZ were examined in vitro. …

Biological & pharmaceutical bulletin 23(7), 844-849, 2000-07-01

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5

Combination of Serine Protease Inhibitor FUT-175 and Thromboxane Synthetase Inhibitor OKY-046 Decreases Cerebral Vasospasm in Patients with Subarachnoid Hemorrhage [in Japanese]

KAMINOGO Makio , YONEKURA Masahiro , ONIZUKA Masanari , YASUNAGA Akio , SHIBATA Shobu

… クモ膜下出血後(SAH)の脳血管攣縮発現に補体活性化を介する炎症反応が関与するとの考えらか、抗補体活性化作用を有するserine protease inhibitor(FUT-175)を従来の抗攣縮治療であるTXA2合成阻害薬(OKY-046)とともに使用し、その有効性に関しFisher group 3の高度なクモ膜下出血症例を対象として検討した。 …

神経外科 38(11), 704-709, 1998-11-15

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6

OKY-046, 1 selective thromboxane A_2 synthesase inhibitor enhances lung preservation in an ex vivo rabbit heart-lung model [in Japanese]

Bhuiyan M.M.R. , Nakamoto Kembu , Okamoto Taku , Sugita Ayanori , Kameyama Kotaro , Hayashi Eiichi , Koseki Masato , Maeda Masazumi

… デルでトロンボキサンA_2合成酵素阻害剤OKY-046のフラッシュ効果と機能温存効果を検討した.in vivo, 30cm落差の前潅流(50ml/kg)で, EP_4液単独滴下を対照群(Grp1, N=10), OKY-046(0.1mmol)添加を実験群(Grp2, N=10)とし, 8℃18時間保存機能評価した.前潅流:Grp1, 2のPAPは10.7±1.0cmH_2O, 9.5±0.33cmH_2Oで, Grp2の方が有意に低値であ …

The journal of the Japanese Association for Chest Surgery 12(4), 454-460, 1998-05-15

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7

Effects of cysteinyl-leukotriene receptor antagonist, thromboxane A_2 receptor antagonist, and thromboxane A_2 synthetase inhibitor on antigen-induced bronchoconstriction in patients with asthma

OBASE Y

Chest 114, 1028-1032, 1998

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8

Hemodynamic analysis of post-reperfusion syndrome and the effect of preventing this syndrome using thromboxane A_2 synthetase inhibitor (OKY-046) in swine liver transplantation

ISHINE N

Transplant Proc 29, 378-381, 1997

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9

Inhibitory Effect of CV4151, a Thromboxane A2 Synthetase Inhibitor, on Ventricular Arrhythmias Induced by Coronary Artery Occlusion in Rats

Umetani Ken , Tamura Kohji , Komori Sadayoshi , Watanabe Akinori , Ishihara Tukasa , Mochizuki Sunao , Li Binghong , Ijiri Hiroshi

… The purpose of this study was to determine whether thromboxane A_2(TXA2)is involved in the development of ventricular arrhythmias produced by coronary artery occlusion. … Rats were separated into 4 groups, and salne(n=19)or CV4151(a TXA2 synthetase inhibitor)(10 mg/kg, n=14 ; …

Japanese circulation journal 60(6), 349-354, 1996-05-20

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10

The Effects Isobogrel (thromboxane A_2 synthetase inhibitor) on Platelet Aggregability Due to Addition of the Vessel [in Japanese]

KANAZAWA Takemichi , OSANAI Tomohiro , MIURA Akiko , ONODERA Kogo , MURAKAMI Shoichi , TAKANASHI Makiko , NAKAMICHI Tokuro

動脈硬化 = The journal of Japan Atherosclerosis Society 23(7), 451-457, 1996-03-30

Ichushi Web References (17)
11

Protective effects of thromboxane A_2 synthetase inhibitor (OKY-046) on hepatic ischemia-reperfusion injury in rats with obstructive jaundice

ORITA MASAHIKO

Journal of hepato-biliary-pancreatic surgery 3(1), 60-65, 1996-03-01

Ichushi Web References (20)
12

The Effects of Thromboxane A_2 Synthetase Inhibitor (OKY-046) on Complete Hepatic Ischemia in Rats with Obstructive Jaundice

TAKAHASHI TSUYOSHI

Surgery today : the Japanese journal of surgery 26(1), 15-20, 1996-01-01

References (27)
13

Synthesis of a Novel Dual Inhibitor of Thromboxane A_2 Synthetase and 5-Lipoxygenase (E3040) via the Direct Coupling Reaction of Hydroquinone with 3-Pyridinecarboealdehyde

KOMATSU Yuki , MINAMI Norio

… of a novel dual inhibitor of thromboxane A_2 synthetase and 5-lipoxygenase, 5,7-dimethyl-6-hydroxy-2-methylamino-4-(3-pyridylmethyl)benzothiazole (E3040), was accomplished via a new coupling reaction, in which a key intermediate, (3,6-dihydroxy-2,4-dimethylphenyl)-(3-pyridyl)methanol, was easily synthesized …

Chemical & pharmaceutical bulletin 43(10), 1614-1616, 1995-10-15

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14

Sodium Orthovanadate Increases Phospholipase A_2 Activity in Isolated Rat Fat Pads : a Role of Phospholipase A_2 in the Vanadate-Stimulated Release of Lipoprotein Lipase Activity

MORITA Tetsuo , IMAGAWA Takao , KANAGAWA Asako , UEKI Hiroshi

… Phospholipase (PL) A_2 activity prepared from isolated rat fat pads incubated with sodium orthovanadate (vanadate) was increased in a time-and dose-dependent manner. … Under the inhibition of protein synthesis by cycloheximide, vanadate still showed a full effect on the increase in PL A_2 activity. …

Biological & pharmaceutical bulletin 18(2), 347-349, 1995-02-15

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15

Pharmacological Profile of F-0401,a Novel Dihydropyridine Derivative. III. The Anti-Aggregatory Action of F-0401 on Rabbit Platelets [in Japanese]

KASE Noriko , TAMURA Norihiko , YAMAURA Tetsuaki , OHNISHI Haruo

… F-0401 is a newly synthesized dihydropyridine derivative with both antagonistic activity on platelet-activating factor (PAF) and inhibitory action on thromboxane A_2 (TXA_2) synthetase activity. …

Journal of the Pharmaceutical Society of Japan 115(1), 52-61, 1995-01-25

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16

腎移植慢性拒絶反応に対するThromboxane A_2 synthetase inhibitorの長期効果 [in Japanese]

今西正昭 , 石井徳味 , 植村匡志 , 国方聖司 , 神田英憲 , 秋山隆弘 , 栗田孝

The Japanese Journal of Urology 86(1), 99, 1995-01-20

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17

Effect of thromboxane-A_2 synthetase inhibitor, OKY-046, on sputum in chronic bronchitis and diffuse panbronchitis

KURASHIMA K

Eur. Respir. J. 8, 1705-1711, 1995

CrossRef Cited by (1)
18

Effects of a thromboxane A_2-receptor antagonist, a thromboxane synthetase inhibitor and aspirin on prostaglandin I_2 production in endothelium-intact and -injured aorta of guinea pigs

HIGO K.

Jpn J Pharmacol 66, 471-479, 1994

Ichushi Web Cited by (1)
19

Effect of DP-1904, a thromboxane A_2 synthetase inhibitor, on crescentic nephritis in rats

NAGAO T.

Eur J Pharmacol 259, 233-242, 1994

Cited by (2)
20

The protective effect of thromboxane A_2 synthetase inhibitor against ischemic liver injury

ISOZAKI H

Surg Today 24, 435-440, 1994

Ichushi Web Cited by (2)

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