Search Results:　 1-20 of 824

1

Photoreactivities of 5-Bromouracil-containing RNAs.

Morinaga Hironobu , Kizaki Seiichiro , Takenaka Tomohiro , Kanesato Shuhei , Sannohe Yuta , Tashiro Ryu , Sugiyama Hiroshi

… The present results indicate clearly that hydrogen (H) abstraction by the photochemically generated uracil-5-yl radical selectively occurs at the C2' position to provide a 2'-keto RNA product. …

Bioorganic & medicinal chemistry 21(2), 466-469, 2013-01-15

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2

Improvement of the growth defect in salt- and ethanol-tolerant yeast mutagenized with error-prone DNA polymerization by using backcross cell fusion(MISCELLANEOUS)

Hayashi Kazukiyo , Yano Shuntaro , Abe Hiroko , Fujita Yasuko , Kishida Masao

… Salt- and ethanol-tolerant mutants of Saccharomyces cerevisiae, isolated from the uracil-requiring mutant derived from Taiken No. 396 by proofreading-deficient DNA polymerization, showed less growth than their parent strain. …

Journal of bioscience and bioengineering 114(4), 476-478, 2012-10-00

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3

Ten-Year Survival of Curability B Gastric Cancer Patients Treated by Tegafur-Uracil as Postoperative Adjuvant Chemotherapy in a Common Public Hospital : Univariate and Multivariate Analyses

奥山稔朗 , 東貴寛 , 枝川愛他

福岡医学雑誌 103(7), 138-144, 2012-07-25
4

Ten-Year Survival of Curability B Gastric Cancer Patients Treated by Tegafur-Uracil as Postoperative Adjuvant Chemotherapy in a Common Public Hospital : Univariate and Multivariate Analyses

Okuyama Toshiro , Higashi Takahiro , Edagawa Ai , Nagata Shigeyuki , Hashimoto Kenkichi , Saeki Hiroshi , Oki Eiji , Uchiyama Hideaki , Kawanaka Hirofumi , Morita Masaru , Tateishi Masahiro , Korenaga Daisuke , Yaita Hidemichi , Takenaka Kenji , 奥山稔朗 , 東貴寛 , 枝川愛 , 永田茂行 , 橋本健吉 , 佐伯浩司 , 沖英次 , 内山秀昭 , 川中博文 , 森田勝 , 立石雅宏 , 是永大輔 , 八板英道 , 竹中賢治 , オクヤマトシロウ , ヒガシタカヒロ , ナガタシゲユキ , ハシモトケンキチ , サエキヒロシ , オキエイジ , ウチヤマヒデアキ , カワナカヒロフミ , モリタマサル , タテイシマサヒロ , コレナガダイスケ , ヤイタヒデミチ , タケナカケンジ

… There were 21 patients who underwent surgery alone with no oral anti-cancer agents (group A) and 65 patients who were treated postoperatively, mainly with UFT (Tegafur and uracil ; …

福岡医学雑誌 103(7), 138-144, 2012-07-25

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5

Oxidative pyrimidine metabolism in Rhodococcus erythropolis useful for valuable nucleoside synthesis: Discovery of a novel amidohydorolase, ureidomalonase

Horinouchi Nobuyuki , Soon Chee-Leong , Shimizu Sakayu , Ogawa Jun

… These finding brought a comprehensive understanding about oxidative pyrimidine metabolism for the first time, which consisted of uracil/thymine dehydrogenase, barbiturase, and ureidomalonase. …

Biocatalysis and Agricultural Biotechnology 1(3), 264-266, 2012-07-00

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6

Isolation of Uracil Auxotrophs of the Fungus Acremonium cellulolyticus and the Development of a Transformation System with the pyrF Gene

FUJII Tatsuya , IWATA Kazuya , MURAKAMI Katsuji , YANO Shinichi , SAWAYAMA Shigeki

… In this study, we isolated a uracil auxotroph (strain CFP3) derived from CF-2612, and cloned a wild-type pyrF … gene restored the defective growth of CFP3 on uracil-free medium, and PCR and Southern analyses revealed that wild-type pyrF …

Bioscience, Biotechnology, and Biochemistry 76(2), 245-249, 2012-02-23

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7

A case of clear cell adenocarcinoma of the lung with long-term survival [in Japanese]

Yamada Eiji , Kataoka Kazuhiko , Fujiwara Toshiya , Matsuura Motoki

… Tegafur-uracil (UFT) was administered orally for 24 months as adjuvant chemotherapy, and the patient has survived for 6 years and 3 months since the surgical resection. …

The Journal of the Japanese Association for Chest Surgery 26(7), 734-738, 2012

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8

A case of successful treatment of granulocyte colony-stimulating factor producing hepatocellular carcinoma accompanying type B hepatitis with tegafur-uracil [in Japanese]

ITO Takanori , OKUBO Kenji , SHIOMI Masaya , NARITA Michihiko , MORITA Kiyoshi , TAKEUCHI Atsufumi , KANAZAWA Hironobu , SHIMIZU Junichi , TAKEYAMA Tomoaki , HASHIZUME Kiyotaka , SHIBAHARA Hiroaki , NISHIMURA Daisaku , KATADA Naoyuki , KATANO Yoshiaki , GOTO Hidemi

… Changing the patient's medication to tegafur-uracil provided remarkable reduction of the lung metastases. …

Nippon Shokakibyo Gakkai Zasshi 109(12), 2088-2096, 2012

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9

Evolution of Macrocyclic Polyamines From Molecular Science to Supramolecular Science

Kimura Eiichi

… 8) selective recognition of a nucleobase thymine (and uracil) in nucleic acids by ZnII-12-membered macrocyclic tetraamine ("cyclen") complexes; …

Bulletin of Japan Society of Coordination Chemistry 59(0), 26-47, 2012

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10

A case of hCG-producing pulmonary pleomorphic carcinoma [in Japanese]

Ban Hidetoshi , Yasumitsu Tsutomu , Yan Dokusun

症例は76歳男性．血痰を主訴に受診し画像診断にて左上葉に腫瘤を認めた．精査にて確定診断に至らなかったが，画像上急激に増大したため肺癌を強く疑い切除術を施行した．病理診断は低分化腺癌を主体とした多形癌で病期はpT2N0M0のため，UFT内服による化学療法を追加した．しかし，術後3ヵ月で縦隔再発を来たし，切除および50 Gyの放射線治療を行い，その後CBDCA＋PTXによる化学療法を3クール施行した． …

The Journal of the Japanese Association for Chest Surgery 26(2), 208-213, 2012

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11

A Phase III study of combination therapy of the oral fluorinated pyrimidine compound tegafur-uracil (UFT) with low dose cisplatin compared with UFT alone in patients with locally advanced gastric cancer as postoperative adjuvant chemotherapy

Gochi Akira , Saji Shigetoyo , Sakamoto Junichi , Hirata Koichi , Tominaga Suketami , Yamaguchi Yoshiyuki , Shibata Masahiko , Kai Yoshiki , Tanemura Hiromi , Shirasaka Tetsuhiko

Background: While surgery remains the sole mainstay of any curative treatment for gastric cancer, the relapse rate is high and survival remains low even after surgical resection with curative intent.M …

Annals of Cancer Research and Therapy 20(1), 17-23, 2012

J-STAGE CrossRef
12

Pneumonic-type Adenocarcinoma with Dissemination Similar to That of Bronchioloalveolar Carcinoma [in Japanese]

Fukai Ryuta , Sagara Hironori , Sakao Yukinori , Miyamoto Hideaki , Uekusa Toshimasa , Suzuki Kenji

背景．気道を介した病変の多発・両側性進展（aerogenous dissemination）は細気管支肺胞上皮癌に典型的であるが，腺癌でも同様の進展を示す場合があり，肺炎型肺腺癌として報告されている．症例．65歳，男性．血痰を主訴に受診，喀痰細胞診で腺癌と診断された．胸部X線写真で，右下葉に一致した肺炎様硬化像を認め，胸部CTでは右下葉内に嚢胞性変化を伴った病変であり，中葉にもわずかに陰影がみられ …

Haigan 52(1), 49-53, 2012

J-STAGE Ichushi Web CrossRef
13

Molecular basis of dihydrouridine formation on tRNA

Yu Futao , Tanaka Yoshikazu , Yamashita Keitaro , Suzuki Takeo , Nakamura Akiyoshi , Hirano Nagisa , Suzuki Tsutomu , Yao Min , Tanaka Isao

… Dihydrouridine synthase (Dus) catalyzes the D formation of tRNA through reduction of uracil base with flavin mononucleotide (FMN) as a cofactor. … In the active site, U20 is stacked on the isoalloxazine ring of FMN, and C5 of the U20 uracil ring is covalently cross-linked to the thiol group of Cys93, implying a catalytic mechanism of D20 formation. … In addition, the involvement of a cofactor molecule in uracil ring recognition was proposed. …

Proceedings of the National Academy of Sciences of the United States of America 108(49), 19593-19598, 2011-12-06

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14

Radiolabeled uracil derivative as a novel SPECT probe for thymidine phosphorylase : suppressed accumulation into tumor cells by target gene knockdown

Li Hua , Zhao Songji , Jin Yongnan , Nishijima Ken-ichi , Akizawa Hiromichi , Ohkura Kazue , Tamaki Nagara , Kuge Yuji

… Objectives: We developed a radiolabeled uracil derivative, 5-iodo-6-[(2-iminoimidazolidinyl)methyl]uracil (IIMU), as a novel SPECT probe for thymidine phosphorylase (TP). …

Nuclear Medicine Communications 32(12), 1211-1215, 2011-12-00

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15

A novel method for introducing a polyfluoroalkyl group into aromatic compounds

Tahara Ryuhei , Fukuhara Tadahito , Hara Shoji

… Selective perfluoroethylation of uracil at the 5-position was also performed. …

Journal of Fluorine Chemistry 132(9), 579-586, 2011-09-00

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16

Characterizing Hydrogen Bonding in Uracil-Nitrosamine Complexes through One- and Two-Bond Spin-Spin Coupling Constants across Hydrogen Bonds

ROOHI Hossein , ANJOMSHOA Elham

Bulletin of the Chemical Society of Japan 84(7), 754-763, 2011-07-15

References (34)
17

Clinical experience of Hochuekkito in hand-foot syndrome [in Japanese]

KUWAHARA TORU , YAMAGUCHI AKIRA , MIZUTANI MASUTAKA , HIROYASU KAZUHIKO , TOYA SHUJI , TAKENO TOSHIHIKO

… We present a case of hand-foot syndrome (HFS) induced by uracil/tegafur (UFT). …

ORAL THERAPEUTICS AND PHARMACOLOGY 30(1), 20-24, 2011-04-01

J-STAGE Ichushi Web References (23)
18

Chemotherapy for Urological Cancer : Usefulness and Feasibility of Current Protocols [in Japanese]

原勲 , 元雄良治

… We dealt with uracil and tegafur (UFT) therapy which has been widely used in Japan. …

泌尿器科紀要 57(3), 151-152, 2011-03-31

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19

Combination chemotherapy of docetaxel and UFT against hormone refractory prostate cancer [in Japanese]

島崎猛夫 , 宮澤克人 , 森山学他

… This study was undertaken to assess the feasibility of docetaxel in combination with UFT (a combination of tegafur and uracil) in Japanese patients with HRPC. …

Acta urologica Japonica 57(3), 163-166, 2011-03-00

IR Ichushi Web
20

Prognostic Factors of Pathologic Stage IB Non-small Cell Lung Cancer

YANO Motoki , SASAKI Hidefumi , MORIYAMA Satoru , KAWANO Osamu , HIKOSAKA Yu , FUJII Yoshitaka

… Purpose: In pathologic IB (pIB) non-small cell lung cancer, especially in adenocarcinoma, adjuvant chemotherapy with uracil-tegafur is widely recognized as being effective. … Results: Of 60 patients, 22 (36.7%) opted for surgery plus adjuvant chemotherapy with uracil-tegafur, whereas 38 (63.3%) opted for surgery only. … The oral administration dose of uracil-tegafur was 400 mg/body. …

Annals of Thoracic and Cardiovascular Surgery 17(1), 58-62, 2011-02-01

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