Studies of Inorganic Crystals in Biological Tissue : Magnetite in Human Tumor

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Ferromagnetic materials, magnetite crystals, have been extracted and identified from magnetotactic bacteria, polyplacophoran mollusks (chitons), salmons, tuna and recently tissues of the human brain. Ferritin, the iron storage nonheme-protein contains hydrated iron oxide (Fe<SUB>2</SUB>O<SUB>3</SUB>-nH<SUB>2</SUB>O) in its core. It is suggested that this hydrated oxide in ferritin would be the precursor of magnetite in both magnetotactic bacteria and the chitons. Many studies have described that ferritin were related with cell proliferation, specially tumor cell growth. In this study, we attempted to investigate the presence of magnetite in tumor tissues. We report the first detection of magnetic materials in various human tumor tissues (melanoma, breast, ovary, testicle, sarcoma, meninginoma, glioblastoma, astrocytoma, glioma, metastasis) with the use of SQUID magnetometry. The magnetometory data for the magnetic materials are consistent with magnetite (Fe<SUB>3</SUB>O<SUB>4</SUB>). Its concentration of various tissue types were measured via sIRMs. Tumor tissues were also stained blue with the Perls staining method for detecting ferritin. Our experiments show that the distribution of magnetite and ferritin in tumor tissues might depend on the etiology of the tumor. Ferritin distribution as indicated through staining suggest an irregular pattern with distinctive foci. However, a spacial covariance between ferritin and magnetite was unable to demonstrate in this study.

収録刊行物

  • 粉体および粉末冶金

    粉体および粉末冶金 44(3), 294-300, 1997-03-15

    Japan Society of Powder and Powder Metallurgy

参考文献:  23件中 1-23件 を表示

  • <no title>

    CRICHITON R. R.

    Iron transport and storage 164, 485, 1987

    被引用文献1件

  • <no title>

    MANN S.

    J. Mol. Biol. 188, 225, 1986

    被引用文献1件

  • <no title>

    LOWENSTAM H. A.

    Science 227, 51, 1985

    被引用文献2件

  • <no title>

    MANN S.

    Adv. Microb. Physiol. 31, 125, 1990

    被引用文献3件

  • <no title>

    MANN S.

    J. Exper. Biol. 140, 35, 1988

    被引用文献2件

  • <no title>

    NESSON H. M.

    A new biomagnetism 333, 1985

    被引用文献2件

  • <no title>

    TAMAURA Y.

    J. Chem. Soc. Dalton Trans. 189, 1983

    被引用文献2件

  • <no title>

    MANN S.

    Nature 36, 499, 1993

    被引用文献2件

  • <no title>

    KOBAYASHI A.

    J. J. Soc. Powder and Powder Metall. 43, 1354, 1996

    被引用文献1件

  • <no title>

    CASSELLA J. P.

    Proc. Roy. Micros. Soc. 25, 41, 1990

    被引用文献2件

  • <no title>

    CASSELLA J. P.

    Metal iron in biology and medicine 104, 1990

    被引用文献1件

  • <no title>

    DRAYER B.

    A. J. N. R. 7, 373, 1986

    被引用文献2件

  • <no title>

    BIZZI A.

    Radiology 177, 59, 1990

    被引用文献2件

  • <no title>

    TAKAI K.

    Hinyou-kiyou 37, 363, 1991

    被引用文献1件

  • <no title>

    JACOBSEN G. K.

    Acta. Pathol. Microbiol. Immunol. Scand. Sect. A. 91, 177, 1983

    被引用文献1件

  • <no title>

    TORTI S. V.

    Adv. Inorg. Biochem. 10, 119, 1994

    被引用文献1件

  • <no title>

    WORWOOD M.

    Clinical Science and Molecular Medicine 48, 441, 1975

    被引用文献1件

  • <no title>

    JOANNE J. T.

    Nature 265, 755, 1977

    被引用文献1件

  • <no title>

    FULLER M.

    A new biomagnetisms 103, 1985

    被引用文献2件

  • <no title>

    KOBAYASHI A.

    Nature 374, 123, 1995

    被引用文献1件

  • <no title>

    MOSKOWITZ B. M.

    Earth and Planeraty Science Letters 120, 283, 1993

    被引用文献1件

  • <no title>

    MOSKOWITZ B. M.

    J. Magn. Mag. Mat. 73, 273, 1988

    被引用文献1件

  • Lepidocrocite, and apatite mineral, and magnetite in teeth of chitons (Polyplacophora)

    LOWENSTAM H. A.

    Science 156, 1373-1375, 1967

    DOI 被引用文献5件

各種コード

  • NII論文ID(NAID)
    10002013717
  • NII書誌ID(NCID)
    AN00222724
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    05328799
  • NDL 記事登録ID
    4172716
  • NDL 雑誌分類
    ZP41(科学技術--金属工学・鉱山工学)
  • NDL 請求記号
    Z17-274
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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