3. 新しいタンパク質立体構造 アミノアシルtRNA合成酵素 : 構造的見地から見た基質認識機構と分子進化 Aminoacyl-tRNA Synthetase : Structural Basis for the Substrate Recognition and the Molecular Evolution

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著者

    • 濡木 理 NUREKI Osamu
    • 東京大学大学院理学系研究科生物化学専攻 Department of Biophysics and Biochemistry, School of Science, University of Tokyo
    • 横山 茂之 YOKOYAMA Shigeyuki
    • 東京大学大学院理学系研究科生物化学専攻 Department of Biophysics and Biochemistry, School of Science, University of Tokyo

抄録

Aminoacyl-tRNA synthetases (aaRS's) play key roles in the correct protein biosynthesis through strict recognition/ligation of the cognate amino acid and tRNA. Twenty aaRS's were evolutionally devided into two classes (class I and class II) based on the architecture of the ATP-binding domain. Our recent result on the crystal structure of class-I aaRS (glutamyl-tRNA synthetase) delineates that aaRS's accomplish their strict recognition of the tRNA through a combination of insertions and deletions of modular structures in the class/subclass-defining domains and a total exchange of the non-conserved anticodon-binding domains. In contrast, structure of ternary complex of aaRS ·ATP ·amino-acid suggests that the strict amino-acid recognition is accomplished through evolutionary accumulation of mutation of the amino acid residues in the amino-acid binding site.

収録刊行物

  • 日本結晶学会誌  

    日本結晶学会誌 38(1), 60-67, 1996-02-28 

    The Crystallographic Society of Japan

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各種コード

  • NII論文ID(NAID)
    10002024753
  • NII書誌ID(NCID)
    AN00188364
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    03694585
  • NDL 記事登録ID
    3934772
  • NDL 雑誌分類
    ZM46(科学技術--地球科学--岩石・鉱物・鉱床)
  • NDL 請求記号
    Z15-138
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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