アミノアシルtRNA合成酵素: 構造的見地から見た基質認識機構と分子進化

• 濡木 理

  東京大学大学院理学系研究科生物化学専攻

• 横山 茂之

  東京大学大学院理学系研究科生物化学専攻

書誌事項

タイトル別名

• Aminoacyl-tRNA Synthetase : Structural Basis for the Substrate Recognition and the Molecular Evolution
• アミノアシル t RNA ゴウセイ コウソ コウゾウテキ ケンチ カラ ミタ

抄録

Aminoacyl-tRNA synthetases (aaRS's) play key roles in the correct protein biosynthesis through strict recognition/ligation of the cognate amino acid and tRNA. Twenty aaRS's were evolutionally devided into two classes (class I and class II) based on the architecture of the ATP-binding domain. Our recent result on the crystal structure of class-I aaRS (glutamyl-tRNA synthetase) delineates that aaRS's accomplish their strict recognition of the tRNA through a combination of insertions and deletions of modular structures in the class/subclass-defining domains and a total exchange of the non-conserved anticodon-binding domains. In contrast, structure of ternary complex of aaRS ·ATP ·amino-acid suggests that the strict amino-acid recognition is accomplished through evolutionary accumulation of mutation of the amino acid residues in the amino-acid binding site.

収録刊行物

• 日本結晶学会誌

  日本結晶学会誌 38 (1), 60-67, 1996

  日本結晶学会

詳細情報

• CRID: 1390001204088601472
• NII論文ID: 10002024753
• NII書誌ID: AN00188364
• DOI: 10.5940/jcrsj.38.60
• ISSN: 18845576
• ISSN: 03694585
• NDL書誌ID: 3934772
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3934772
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