3. 新しいタンパク質立体構造 NADH-チトクロムb_5還元酵素の結晶構造とフラビン依存性還元酵素での電子伝達 Crystal Structure of NADH-cytochrome b_5 Reductase and Electron Transfer in Flavin-dependent Reductases

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The structure of NADH-cytochrome bs reductase has been determined and refined at 2.1 Å resolution. The molecular structure reveals its two domain nature, the FAD binding domain and the NADH domain. Structural difference between the FAD-binding site of this enzyme and that of ferredoxin-NADP<SUP>+</SUP> reductase gives an explanation about the difference of their enzymatic reaction with nucleotides. Three conserved amino acid residues interact significantly with the flavin molecules in four flavin-dependent reductases whose molecular structures have a similar folding pattern in spite of their relative low sequence identity. The electrostatic potentials on the molecular surfaces were compared among these four flavin-dependent reductases and their electron-transfer partners.

収録刊行物

  • 日本結晶学会誌

    日本結晶学会誌 38(1), 73-79, 1996-02-28

    The Crystallographic Society of Japan

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  • NII論文ID(NAID)
    10002024822
  • NII書誌ID(NCID)
    AN00188364
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    03694585
  • NDL 記事登録ID
    3934774
  • NDL 雑誌分類
    ZM46(科学技術--地球科学--岩石・鉱物・鉱床)
  • NDL 請求記号
    Z15-138
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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