X線回折による筋収縮分子機構の研究 X-Ray Diffraction and Scattering Studies on Molecular Mechanism of Muscle Contraction

この論文にアクセスする

この論文をさがす

著者

    • 若林 克三 WAKABAYASHI Katsuzo
    • 大阪大学基礎工学部生物工学科生物物理学研究室 Department of Biophysical Engineering, Faculty of Engineering Science, Osaka University

抄録

The molecular mechanism of muscle contraction has been investigated by X-ray diffraction and scattering. Intense synchrotron X-rays and a novel area detector enabled us to detect a tiny but significant intensity and spacing changes of the weaker actin-based reflections during muscle contraction with high accuracy. Our analyses have shown that the structural changes and extensibility of the actin filament play an important role in force-generation of muscle, necessitating quite significant reevaluation of the current models of crossbridge mechanism. Although the structural changes within crossbridges which produce force in muscle remain to be clarified, our recent X-ray solution scattering has showed distinct alterations of the structure of myosin heads during hydrolysis of ATP. For a real understanding of the force transduction in muscle, we need explicit structural models that explain the coupling between the structural changes in actin and myosin. This special report makes a survey of our recent progress in the X-ray structural reseach of muscle, on occasion for a Japan Crytallographic Society award.

収録刊行物

  • 日本結晶学会誌  

    日本結晶学会誌 38(3), 208-220, 1996-06-30 

    The Crystallographic Society of Japan

参考文献:  52件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10002025099
  • NII書誌ID(NCID)
    AN00188364
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    03694585
  • NDL 記事登録ID
    3984491
  • NDL 雑誌分類
    ZM46(科学技術--地球科学--岩石・鉱物・鉱床)
  • NDL 請求記号
    Z15-138
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ