短鎖型脱水素酵素/還元酵素ファミリーに属する酵素の構造と機能 Structure and Function of the enzymes belonging to the SDR (Short-chain Dehydrogenase/Reductase) Family

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A group of short-chain dehydrogenases/reductases (SDR) has recently been identified. These enzymes utilize NAD (H) or NADP (H) as cofactors and exhibit a wide variety of substrate specificities. Crystal structure analyses have been completed for some of these enzymes, but none of them have targeted the ternary (enzyme-coenzyme-substrate analogue) complexes.<BR>We have recently solved the crystal structures of the ternary complex (with NAD (H) ) of 7α-hydroxysteroid dehydrogenase from <I>E. coli </I>and that (with NADP (H) ) of mouse lung carbonyl reductase. These two structures enabled us to discuss the catalytic mechanism and the origin of coenzyme specificities (NAD (H) or NADP (H) ) common to the enzymes of the SDR family.

収録刊行物

  • 日本結晶学会誌  

    日本結晶学会誌 38(3), 235-243, 1996-06-30 

    The Crystallographic Society of Japan

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各種コード

  • NII論文ID(NAID)
    10002025209
  • NII書誌ID(NCID)
    AN00188364
  • 本文言語コード
    JPN
  • 資料種別
    OTR
  • ISSN
    03694585
  • NDL 記事登録ID
    3984494
  • NDL 雑誌分類
    ZM46(科学技術--地球科学--岩石・鉱物・鉱床)
  • NDL 請求記号
    Z15-138
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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