Structure and Function of the enzymes belonging to the SDR(Short-chain Dehydrogenase/Reductase) Family.

• TANAKA Nobutada

  長岡技術科学大学生物系三井研究室

Bibliographic Information

Other Title

• 短鎖型脱水素酵素／還元酵素ファミリーに属する酵素の構造と機能
• タンサガタ ダツ スイソ コウソ カンゲン コウソ ファミリーニ ゾクスル コ

Abstract

A group of short-chain dehydrogenases/reductases (SDR) has recently been identified. These enzymes utilize NAD (H) or NADP (H) as cofactors and exhibit a wide variety of substrate specificities. Crystal structure analyses have been completed for some of these enzymes, but none of them have targeted the ternary (enzyme-coenzyme-substrate analogue) complexes.<BR>We have recently solved the crystal structures of the ternary complex (with NAD (H) ) of 7α-hydroxysteroid dehydrogenase from E. coli and that (with NADP (H) ) of mouse lung carbonyl reductase. These two structures enabled us to discuss the catalytic mechanism and the origin of coenzyme specificities (NAD (H) or NADP (H) ) common to the enzymes of the SDR family.

Journal

• Nihon Kessho Gakkaishi

  Nihon Kessho Gakkaishi 38 (3), 235-243, 1996

  The Crystallographic Society of Japan

Details

• CRID: 1390001204087201152
• NII Article ID: 10002025209
• NII Book ID: AN00188364
• DOI: 10.5940/jcrsj.38.235
• ISSN: 18845576
• ISSN: 03694585
• ISSN: http://id.crossref.org/issn/09692126
• NDL BIB ID: 3984494
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3984494
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed