Positron Emission Tomography for Evaluation of Dopaminergic Function Using a Neurotransmitter Analog L-¹⁸F-m-Tyrosine in Monkey Brain

• Tomiyoshi Katsumi

  Department of Nuclear Medicine, Gunma University School of Medicine

• Hirano Tsuneo

  Department of Nuclear Medicine, Gunma University School of Medicine

• lnoue Tomio

  Department of Nuclear Medicine, Gunma University School of Medicine

• Oriuchi Noboru

  Department of Nuclear Medicine, Gunma University School of Medicine

• Tateno Madoka

  Department of Nuclear Medicine, Gunma University School of Medicine

• Endo Keigo

  Department of Nuclear Medicine, Gunma University School of Medicine

• Hayase Noriaki

  Department of Neurosurgery, Gunma University School of Medicine

• Watanabe Katsunari

  Department of Neurosurgery, Gunma University School of Medicine

• Shibazaki Takashi

  Department of Neurosurgery, Gunma University School of Medicine

• Ohye Chihiro

  Department of Neurosurgery, Gunma University School of Medicine

抄録

6-[¹⁸F] Fluorine-3,4-dihydroxyphenyl-L-alanine (¹⁸F-Dopa) was used for the diagnosis of malfunction of the D₂ dopaminergic presynaptic system with positron emission tomography (PET). However ¹⁸F-Dopa has multiple metabolic pathways: for example, it is metabolized to 3-O-methyl-6-¹⁸F-4- hydroxyphenylalanine, which deteriorate the images of ¹⁸F-dopamine. In order to eliminate such contaminations, L-¹⁸F-meta-tyrosine (L-¹⁸FmT) was synthesized and used to obtain clear images of high uptake of L-¹⁸FmT on the striatum of four normal monkeys.<br>  Two models of Parkinson's disease were generated by injection of 1-methy-4-phenyl-1,2,3,6-tetra hydropyridine in the monkey. Dynamic and static images were obtained after intravenous injection of 185 MBq of L-¹⁸FmT, using a high-resolution animal PET system SHR-2000. In the normal monkey, there was a symmetrical uptake of L-¹⁸FmT specifically on the striatum with a striatum-to-occipital lobe uptake ratio of about 4.0 at 110 min after injection. On the other hand, in the Parkinson model there was no uptake on the diseased side of the striatum. These results indicate that L-¹⁸FmT is a good radiotracer for imaging of D₂ dopaminergic presynaptic function.

収録刊行物

• bioimages

  bioimages 4 (1), 1-7, 1996

  日本バイオイメージング学会

キーワード

• L-¹⁸F-meta-tyrosine
• PET
• neurotransmitter analog

詳細情報

• CRID: 1390289321268235648
• NII論文ID: 10002037631
• NII書誌ID: AA11084187
• DOI: 10.11169/bioimages.4.1
• ISSN: 09192719
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可