Surface Dissolution-Bulk Erosion Model of Drug Release from Biodegradable Polymer Rods
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A combined model of surface dissolution of the drug and bulk erosion of the polymer is developed for describing the biphasic release profile of drugs from biodegradable polymer rod devices. The model parameters are determined from the conventional moment analysis of the time course of the release profile. The model describes well the typical biphasic phenomena of drug release, the initial bursting release due to dissolution of the surface drug molecules, and the late bursting caused by the bulk erosion of biodegradable polymers.
- JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 31(4), 648-651, 1998-08
The Society of Chemical Engineers, Japan