Solvent Extraction and QSPR of Catecholamines with a Bis(2-ethylhexyl) Hydrogen Phosphate

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In order to develop an effective separation process for catecholamine (CA), a basic investigation on solvent extraction of dopamine (DA), adrenaline (Ad) and noradrenaline (NA) from hydrochloric acid solution and their stripping is conducted at 30°C employing bis(2-ethylhexyl) hydrogen phosphate (D2EHPA) in chloroform, <I>n</I>-hexane and toluene as the organic diluents. From the dependencies of the distribution ratios on the concentrations of reactant species, i.e. CA, hydrogen ion and D2EHPA, it is elucidated that CA (RNH<SUB>2</SUB>) is extracted with D2EHPA (HR′) according to the ion exchange mechanism, as the complex type, RNH<SUB>3</SUB>R′(HR′)<SUB>3</SUB>, and the equilibrium constants (<I>K</I><SUB>ex, CA</SUB>) for the extraction reactions are also evaluated. The quantitative structure property relationship (QSPR) of <I>K</I><SUB>ex, CA</SUB> values for each organic diluent is discussed using molecular modeling with semi-empirical molecular orbital calculations considering the solvent effect.

収録刊行物

  • Journal of chemical engineering of Japan  

    Journal of chemical engineering of Japan 32(1), 76-81, 1999-02 

    The Society of Chemical Engineers, Japan

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各種コード

  • NII論文ID(NAID)
    10002067128
  • NII書誌ID(NCID)
    AA00709658
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    00219592
  • NDL 記事登録ID
    4665098
  • NDL 雑誌分類
    ZP1(科学技術--化学・化学工業)
  • NDL 請求記号
    Z53-R395
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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