β-リン酸三カルシウム-ポリ乳酸共重合体複合体の生理食塩水中における機械的強度変化 [in Japanese] Mechanical Strength Changes of β-Tricalcium Phosphate-Copolymerized Poly-L-Lactide Composites in Physiological Saline [in Japanese]
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New composites of bioactive β-tricalcium phosphate (TCP) and biodegradable copolymerized poly-L-lactide (CPLA) were prepared by a heat-kneading method. Mechanical strength was evaluated by a three-point bending test as a function of soaking time in physiological saline. The mechanical strength of the composites rapidly decreased from 60 to 30 MPa and reached plateau 4 weeks after soaking, while that of pure CPLA was almost constant for the initial 4 weeks and rapidly decreased from 4 weeks after soaking due to the hydrolysis of CPLA. It was indicated from Ca concentration measurements and SEM observations that the initial decreasing in the mechanical strength of the composite was caused by the dissolution of TCP from the surface, and that TCP in the composite inhibited the hydrolysis of CPLA. These results showed that the TCP/ CPLA composites kept the strength for sufficient period to use as biodegradable bone regeneration materials.
- Journal of the Society of Inorganic Materials, Japan
Journal of the Society of Inorganic Materials, Japan 5(277), 493-497, 1998-11-01
The Society of Inorganic Materials, Japan