β-リン酸三カルシウム-ポリ乳酸共重合体複合体の生理食塩水中における機械的強度変化

• 菊池 正紀

  無機材質研究所

• 田中 順三

  無機材質研究所

• 有賀 利郎

  大日本インキ化学工業株式会社

• 田代 豊

  大日本インキ化学工業株式会社

書誌事項

タイトル別名

• Mechanical Strength Changes of β-Tricalcium Phosphate-Copolymerized Poly-L-Lactide Composites in Physiological Saline
• ベータ リンサン 3 カルシウム ポリ ニュウサン キョウ ジュウゴウタイ フ

抄録

New composites of bioactive β-tricalcium phosphate (TCP) and biodegradable copolymerized poly-L-lactide (CPLA) were prepared by a heat-kneading method. Mechanical strength was evaluated by a three-point bending test as a function of soaking time in physiological saline. The mechanical strength of the composites rapidly decreased from 60 to 30 MPa and reached plateau 4 weeks after soaking, while that of pure CPLA was almost constant for the initial 4 weeks and rapidly decreased from 4 weeks after soaking due to the hydrolysis of CPLA. It was indicated from Ca concentration measurements and SEM observations that the initial decreasing in the mechanical strength of the composite was caused by the dissolution of TCP from the surface, and that TCP in the composite inhibited the hydrolysis of CPLA. These results showed that the TCP/ CPLA composites kept the strength for sufficient period to use as biodegradable bone regeneration materials.

収録刊行物

• 無機マテリアル

  無機マテリアル 5 (277), 493-497, 1998

  無機マテリアル学会

キーワード

• β-Tricalcium phosphate (TCP)
• Copolymerized poly-L-lactide (CPLA)
• Composite
• Physiological saline
• Mechanical strength

詳細情報

• CRID: 1390001205389840000
• NII論文ID: 10002124838
• NII書誌ID: AN10455831
• ISSN: 13407899
• ISSN: 2185436X
• DOI: 10.11451/mukimate1994.5.493
• NDL書誌ID: 4590656
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4590656
• データソース種別:
  • JaLC
  • NDL
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可