Aerosolization of a Chelating Agent,Ca-DTPA,for Emergent Inhalation Therapy

DOI Web Site 被引用文献1件 参考文献7件
  • 山田 裕司
    Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
  • 小泉 彰
    Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
  • 福田 俊
    Division of Radiotoxicology and Protection, National Institute of Radiological Sciences

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タイトル別名
  • Aerosolization of Chelating Agent, Ca-DTPA, for Emergent Inhalation Therapy.
  • Aerosolization of a Chelating Agent Ca

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Aerosolization of the chelating agent, Ca-DTPA (diethylenetriaminepentaacetic acid), was studied for removal of inhaled radioactive particles. Four methods of generating aerosols from the powder and from the solution were examined. The particle size and concentration of the Ca-DTPA aerosols were measured by the API Aero-Sizer. The aerosol particles generated by the dry powder inhaler were over 40μm in MMAD (Mass Median Aerodynamic Diameter) and might be too large for administration to the deep lung. The sizes of aerosol particles generated by other three methods (dispersion dust generator, compressed air nebulizer and ultrasonic nebulizer) ranged from 2 to 15μm in MMAD, and those concentrations were over 10mg/m3 at maximum. The generated chelate aerosols were evaluated as inhalable and applicable for inhalation therapy.

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  • 保健物理

    保健物理 32 (2), 167-172, 1997

    日本保健物理学会

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