Aerosolization of a Chelating Agent, Ca-DTPA, for Emergent Inhalation Therapy

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著者

    • 山田 裕司 YAMADA Yuji
    • Division of Radiotoxicology and Protection, National Institute of Radiological Sciences Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
    • 小泉 彰 KOIZUMI Akira
    • Division of Radiotoxicology and Protection, National Institute of Radiological Sciences Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
    • 福田 俊 FUKUDA Satoshi
    • Division of Radiotoxicology and Protection, National Institute of Radiological Sciences Division of Radiotoxicology and Protection, National Institute of Radiological Sciences

抄録

Aerosolization of the chelating agent, Ca-DTPA (diethylenetriaminepentaacetic acid), was studied for removal of inhaled radioactive particles. Four methods of generating aerosols from the powder and from the solution were examined. The particle size and concentration of the Ca-DTPA aerosols were measured by the API Aero-Sizer. The aerosol particles generated by the dry powder inhaler were over 40μm in MMAD (Mass Median Aerodynamic Diameter) and might be too large for administration to the deep lung. The sizes of aerosol particles generated by other three methods (dispersion dust generator, compressed air nebulizer and ultrasonic nebulizer) ranged from 2 to 15μm in MMAD, and those concentrations were over 10mg/m<sup>3</sup> at maximum. The generated chelate aerosols were evaluated as inhalable and applicable for inhalation therapy.

収録刊行物

  • 保健物理 : hoken buturi  

    保健物理 : hoken buturi 32(2), 167-172, 1997-06-30 

    Japan Health Physics Society

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各種コード

  • NII論文ID(NAID)
    10002136477
  • NII書誌ID(NCID)
    AN00228458
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03676110
  • NDL 記事登録ID
    4247997
  • NDL 雑誌分類
    ZN36(科学技術--原子力工学・工業) // ZS45(科学技術--医学--放射線医学)
  • NDL 請求記号
    Z16-696
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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