Effects of DTPA Therapy on Removal of Inhaled High-fired Plutonium Oxide in Rats

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著者

    • 福田 俊 FUKUDA Satoshi
    • 放射線医学総合研究所内部被曝・防護研究部 Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
    • 飯田 治三 IIDA Haruzo
    • 放射線医学総合研究所内部被曝・防護研究部 Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
    • 山田 裕司 [他] YAMADA Yuji
    • 放射線医学総合研究所内部被曝・防護研究部 Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
    • 小泉 彰 KOIZUMI Akira
    • 放射線医学総合研究所内部被曝・防護研究部 Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
    • 石榑 信人 ISHIGURE Nobuto
    • 放射線医学総合研究所内部被曝・防護研究部 Division of Radiotoxicology and Protection, National Institute of Radiological Sciences

抄録

The effects of chelation therapy by combined administration of Ca-DTPA and Zn-DTPA on the removal of inhaled "high-fired" plutonium oxide initiated at different times after exposure were examined in rats. After inhalation of plutonium oxide, the rats were divided into four groups of five. Chelation therapy was initiated 1 day after the inhalation in the first group, 7 days after in the second group, and 14 days after in the third group, the final group was a control (no DTPA treatment). A daily dose of 150μmol/kg of Ca-DTPA was administered by peritoneal injection for the first four days and subsequently, a same dose of Zn-DTPA was given orally for 26 days. In order to examine the effects of chelation therapy, we measured lung retention of plutonium with a phoswich detector, the amount of plutonium in excreta after Ca-DTPA injection, and the plutonium contents in various organs at the end of the experiment. The results indicate that DTPA therapy is not effective in removing "high-fired" plutonium oxide from the body.

収録刊行物

  • 保健物理 : hoken buturi  

    保健物理 : hoken buturi 32(4), 383-386, 1997-12-01 

    Japan Health Physics Society

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各種コード

  • NII論文ID(NAID)
    10002136710
  • NII書誌ID(NCID)
    AN00228458
  • 本文言語コード
    ENG
  • 資料種別
    NOT
  • ISSN
    03676110
  • NDL 記事登録ID
    4379487
  • NDL 雑誌分類
    ZN36(科学技術--原子力工学・工業) // ZS45(科学技術--医学--放射線医学)
  • NDL 請求記号
    Z16-696
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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