Effects of DTPA Therapy on Removal of Inhaled High-fired Plutonium Oxide in Rats.
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- FUKUDA Satoshi
- Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
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- IIDA Haruzo
- Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
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- YAMADA Yuji
- Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
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- KOIZUMI Akira
- Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
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- ISHIGURE Nobuto
- Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
Bibliographic Information
- Other Title
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- Effects of DTPA Therapy on Removal of I
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Abstract
The effects of chelation therapy by combined administration of Ca-DTPA and Zn-DTPA on the removal of inhaled “high-fired” plutonium oxide initiated at different times after exposure were examined in rats. After inhalation of plutonium oxide, the rats were divided into four groups of five. Chelation therapy was initiated 1 day after the inhalation in the first group, 7 days after in the second group, and 14 days after in the third group, the final group was a control (no DTPA treatment). A daily dose of 150μmol/kg of Ca-DTPA was administered by peritoneal injection for the first four days and subsequently, a same dose of Zn-DTPA was given orally for 26 days. In order to examine the effects of chelation therapy, we measured lung retention of plutonium with a phoswich detector, the amount of plutonium in excreta after Ca-DTPA injection, and the plutonium contents in various organs at the end of the experiment. The results indicate that DTPA therapy is not effective in removing “high-fired” plutonium oxide from the body.
Journal
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- Japanese Journal of Health Physics
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Japanese Journal of Health Physics 32 (4), 383-386, 1997
Japan Health Physics Society
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Details 詳細情報について
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- CRID
- 1390001204288732160
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- NII Article ID
- 10002136710
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- NII Book ID
- AN00228458
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- COI
- 1:CAS:528:DyaK1cXmvVOjuw%3D%3D
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- ISSN
- 18847560
- 03676110
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- NDL BIB ID
- 4379487
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed