Effects of Four CBMIDA Analogues on Removal of Plutonium in Rats

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著者

    • 福田 俊 FUKUDA Satoshi
    • 放射線医学総合研究所内部被ばく・防護研究部 Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
    • 飯田 治三 IIDA Haruzo
    • 放射線医学総合研究所内部被ばく・防護研究部 Division of Radiotoxicology and Protection, National Institute of Radiological Sciences
    • CHEN Wenzhi
    • 中国科学院上海薬物研究所 Shanghai Institute of Materia Medica, Chinese Academy of Sciences

抄録

We have previously reported that the injection of a newly developed chelating agent, catechol-3, 6-bis (methyleneiminodiacetic acid) (CBMIDA), removes plutonium particularly from the bones, more effectively than DTPA in rats. Nevertheless, the removed plutonium is later redistributed to the kidneys, an undesirable phenomenon, in chelation therapy. Therefore, it was considered of interest to survey the effects of four new analogues of CBMIDA (C-I-C-IV) on the removal of plutonium in rats and compared with the CBMIDA. After the intravenous injection of plutonium, CBMIDA and its analogues were administered daily, for 2 weeks by intraperitoneal injection or by oral administration. The gathered data indicated that the intraperitoneal administration of two analogues, C-II and C-III significantly decreased the amount of plutonium in the bones and liver (<i>p</i><0.01), and that in the spleen, testis and kidney were also reduced. In conclusion, the results indicate that among the tested agents, these two chelating agents present useful characteristics for the chelation therapy in individuals contaminated with plutonium.

収録刊行物

  • 保健物理 : hoken buturi  

    保健物理 : hoken buturi 33(3), 331-336, 1998-09 

    Japan Health Physics Society

参考文献:  14件

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各種コード

  • NII論文ID(NAID)
    10002137418
  • NII書誌ID(NCID)
    AN00228458
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03676110
  • NDL 記事登録ID
    4585341
  • NDL 雑誌分類
    ZN36(科学技術--原子力工学・工業) // ZS45(科学技術--医学--放射線医学)
  • NDL 請求記号
    Z16-696
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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