Delay of Hair Regrowth in Mice as a Possible Biological Dosimeter on the Skin in Case of Over Exposure

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The delay of hair regrowth of mice after irradiation was examined to investigate its possibility as a biological dosimeter in the cases of localized over exposure. Hairs on the dorsal skin of mice were shaved and irradiated with a <sup>90</sup>Sr/<sup>90</sup>Y β-ray source in early anagen or midanagen stage of hair cycle. Skin doses were 0.5-10Gy and 1-4Gy, respectively. Hair regrowth was observed with a scaling loupe. Hair regrowth delay was dose dependent, fitting the linear-quadratic function and the linear function according to the stages of hair. Histological observations indicated that the hair matrix cells death was the main cause of hair regrowth delay in the midanagen stage. Dose estimation functions, derived from the dose-effect relationship curves, could be applied for the dosimetey of the skin over exposure. It could detect a dose over 1Gy, and as early as a few days after the exposure.

収録刊行物

  • 保健物理 : hoken buturi  

    保健物理 : hoken buturi 33(4), 395-399, 1998-12-01 

    Japan Health Physics Society

参考文献:  14件

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各種コード

  • NII論文ID(NAID)
    10002137449
  • NII書誌ID(NCID)
    AN00228458
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    03676110
  • NDL 記事登録ID
    108451
  • NDL 雑誌分類
    ZN36(科学技術--原子力工学・工業) // ZS45(科学技術--医学--放射線医学)
  • NDL 請求記号
    Z16-696
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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