Delay of Hair Regrowth in Mice as a Possible Biological Dosimeter on the Skin in Case of Over Exposure
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The delay of hair regrowth of mice after irradiation was examined to investigate its possibility as a biological dosimeter in the cases of localized over exposure. Hairs on the dorsal skin of mice were shaved and irradiated with a <sup>90</sup>Sr/<sup>90</sup>Y β-ray source in early anagen or midanagen stage of hair cycle. Skin doses were 0.5-10Gy and 1-4Gy, respectively. Hair regrowth was observed with a scaling loupe. Hair regrowth delay was dose dependent, fitting the linear-quadratic function and the linear function according to the stages of hair. Histological observations indicated that the hair matrix cells death was the main cause of hair regrowth delay in the midanagen stage. Dose estimation functions, derived from the dose-effect relationship curves, could be applied for the dosimetey of the skin over exposure. It could detect a dose over 1Gy, and as early as a few days after the exposure.
- Jpn. J. Health Phys.
Jpn. J. Health Phys. 33(4), 395-399, 1998-12-01
Japan Health Physics Society