書誌事項
- タイトル別名
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- .ALPHA.-Tocopherol Transfer Protein and Familial Vitamin E Deficiency.
- ビタミン E ユソウ タンパクシツ ト センテンセイ ビタミン E ケツボウシ
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抄録
α-tocopherol, the most biologically active form of vitamin E, is a lipid soluble antioxidant that protects membranes from oxidative stresses. Vitamin E occurs in nature in eight different forms, but animal body is enriched in α-tocopherol compared with other forms. Studies on the transport of vitamin E in animals and man suggest that the liver plays a key role in the preferential retention, and subsequent distribution of α-tocopherol to tissues, but little is known about the mechanism. We have purified α-tocopherol transfer protein (α TTP) from rat liver and cloned its cDNA. α TTP specifically binds α-tocopherol and enhances its transfer between membranes. Furthermore, we have identified α TTP is abnormal in the patients with familial isolated vitamin E deficiency. In conclusion, α TTP plays a key role in discrimination of tocopherols as well as determination of serum vitamin E concentrations.
収録刊行物
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- 日本油化学会誌
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日本油化学会誌 45 (5), 425-434, 1996
公益社団法人 日本油化学会
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詳細情報
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- CRID
- 1390282679069356032
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- NII論文ID
- 10002269036
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- NII書誌ID
- AN10512582
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- ISSN
- 18841996
- 13418327
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- NDL書誌ID
- 3967149
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可