Purification of EPA Ethyl Ester from Fish Oil with a Supercritical CO2 Temperature Gradient Rectification Column.

• SUZUKI Hiromasa

  Daiichi Pure Chemicals Co., LTD

• Chen JUN

  Dept. of Agricultural Process Engineering, Jiangsu Science and Polytechnic Univ.

• ADSCHIRI Tadafumi

  Dept. of Biochemistry & Engineering, Tohoku Univ.

• INOMATA Hiroshi

  Dept. of Biochemistry & Engineering, Tohoku Univ.

• ARAI Kunio

  Dept. of Biochemistry & Engineering, Tohoku Univ.

Bibliographic Information

Other Title

• 温度勾配を付与した超臨界二酸化炭素精留塔を用いたＥＰＡ‐Ｅｔの高度精製
• オンド コウバイ オ フヨシタ チョウリンカイ 2サンカタンソ セイリュウトウ

Abstract

Ethyl icosapentaenoic acid (EPA-Et) was concentrated from fish oil with Supercritical CO₂ using a rectification column in 9.7 mm internal diameter and 1100 mm effective height. To improve supercritical fluid-liquid contact, “Tawashi” rotor was placed in the extraction cell and the column was packed with Dixon Packing. For greater separation capacity, the column temperature gradient from bottom to top was 35 to 80°C. As the result, reflux flow, waterfall-like in appearance, could be seen, and EPA attained a maximum 90%, although C_{20 : 4} components were abundantly present in the experimental feedstock. It is thus evident from the present study that EPA can be separated from C_{20 : 4} components by Supercritical CO₂ extraction using rectification column optimized with supercritical CO₂-Liquid contact and minimal backmixing.

Journal

• Journal of Japan Oil Chemists' Society

  Journal of Japan Oil Chemists' Society 46 (3), 331-340, 1997

  Japan Oil Chemists' Society

Keywords

• gas liquid contact
• supercritical fluid extraction
• icosapentaenoic acid
• rectification column

Details

• CRID: 1390001204090913664
• NII Article ID: 10002272168
• NII Book ID: AN10512582
• DOI: 10.5650/jos1996.46.331
• COI: 1:CAS:528:DyaK2sXit1Wiu7o%3D
• ISSN: 18841996
• ISSN: 13418327
• NDL BIB ID: 4172700
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4172700
• Web Site: https://www.jstage.jst.go.jp/article/jos1996/46/3/46_3_331/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed