Synthesis of Hydrophilic Fluorosilane Coupling Oligomers Possessing Anti-Human Immunodeficiency Virus Type-1 Activity

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  • SAWADA Hideo
    Department of Chemistry, Nara National College of Technology Department of Chemistry, Faculty of Advanced Engineering, Nara National College of Technology
  • IKEMATSU Yuka
    Department of Chemistry, Faculty of Advanced Engineering, Nara National College of Technology
  • BABA Masanori
    Division of Human Retroviruses, Center for Chronic Viral Diseases, Faculty of Medicine, Kagoshima University
  • KAWASE Tokuzo
    Faculty of Human Life Science, Osaka City University
  • HAYAKAWA Yoshio
    National Industrial Research Institute of Nagoya

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  • 抗エイズウイルス活性を有する親水性フルオロシランカップリングオリゴマーの合成
  • Synthesis of Hydrophilic Fluorosilane C

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Abstract

New fluoroalkyl end-capped oligomeric silane coupling agents were prepared by reactions of fluoroalkanoyl peroxides with trimethylvinylsilane, trimethoxyvinylsilane and acrylic acid. Fluoroalkylated co-oligomers thus obtained were found to be soluble not only in water but common organic solvents as well. The co-oligomers had a good hydrophilicity with a strong oleophobicity above the surface. They were also noted to possess a potent and selective anti-HIV-1 activity even under crosslinked conditions.

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