古細菌脂質膜モデルと機能 [in Japanese] Structure and Functions of Archaebacterial Lipid Membranes [in Japanese]
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古細菌脂質は疎水基が炭素数20, 25, 40の飽和イソプレノイドであり, グリセロール部にエーテル結合している。脂質の分子集合体 (一重膜, 二重膜, キュービック相) は高温度でも安定であり, リポソームは物質保持力に大変優れている。また, 表面エネルギーが異常に低く, 中には炭化フッ素化合物に近い疎水性を示すものがある。古細菌脂質の特徴と機能を飽和イソプレノイド鎖の流動性と立体効果に関連付けつつ概説。
Archaebacterial lipids are featured by C<SUB>20<SUP>-</SUP></SUB>, C<SUB>25<SUP>-</SUP></SUB>and C<SUB>40<SUP>-</SUP></SUB>polyisoprenoid chains connected to a glycerol moiety by an ether linkage. The polyisoprenoid lipids including model compounds gave rise to double layer, unilayer and Q phase-like membranes. The morphology depended strongly on the structure of the lipids. The liposomal membranes made of the polyisoprenoid lipids were very stable at high temperature without undergoing morphological perturbation. The membranes were highly resistant to permeation of protons and various organic compounds as well as inorganic salts. It was also found that the surface energy of the molecular assemblies were extraordinally low, some approaching to the value of fluorocabon materials. These properties and functions were explained by fluidity of each polyisoprenoid chain and rigidity of an polyisoprenoid chain-array in the membranes.
- Journal of Oleo Science
Journal of Oleo Science 46(5), 539-550, 1997-05-20
Japan Oil Chemists' Society