アルキルトリメチルアンモニウム臭素化物によるリポソーム膜崩壊機構

• 小出 操

  ライオン株式会社研究開発本部薬品研究所

• 宇川 仁太

  大阪市立大学工学部生物応用化学科

• 豊嶋 俊薫

  大阪市立大学工学部生物応用化学科

• 太垣 和一郎

  大阪市立大学工学部生物応用化学科

• 玉垣 誠三

  大阪市立大学工学部生物応用化学科

書誌事項

タイトル別名

• Mechanistic Aspects of Membrane Destruction of Dipalmitoylphosphatidylcholine Liposomes by Alkyltrimethylammonium Bromides
• アルキルトリメチルアンモニウム シュウソカブツ ニヨル リポソーム マク ホウ

抄録

The membrane permeability of carboxyfluorescein (CF) trapped dipalmitoylphosphatidylcholine liposomes was facilitated by the presence of long-chain alkyltrimethylammonium bromides (ATAB) and characteristic dependency of this parameter on concentration and alkyl-chain length was noted. Octyl- and decyltri-methylammonium bromides had little or no effect for CF release, while this release was augmented by dodecyl- and tetradecyltrimethylammonium in proportion to concentrations. For longer chain cetyl- and stearyltrimethylammonium bromides exhibiting an abnormal activity-concentration relationship, CF release was remarkably stimulated at significantly low concentrations, while virtually not at all at high concentrations. Based on the data from light-scattering study and differential scanning calorimetry, a CF-releasing mechanism is proposed. The preparation and destruction of liposomes containing anti-inflammatory drugs glycyrrhizinic acid and methylglycyrrhizinate as membrane components were also examined.

収録刊行物

• 日本油化学会誌

  日本油化学会誌 46 (8), 879-890,937, 1997

  公益社団法人 日本油化学会

キーワード

• long-chain alkylammonium salts
• dipalmitoylphosphatidylcholine
• liposome
• carboxyfluorescein
• glycyrrhizinic acid
• membrane permeability

詳細情報

• CRID: 1390282679068108800
• NII論文ID: 10002273074
• NII書誌ID: AN10512582
• DOI: 10.5650/jos1996.46.879
• ISSN: 18841996
• ISSN: 13418327
• NDL書誌ID: 4285213
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4285213
• Web Site: https://www.jstage.jst.go.jp/article/jos1996/46/8/46_8_879/_pdf
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  • NDL
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