臨床現場から見た過酸化脂質測定の意義

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  • Clinical Evaluation in the Measurement of Lipid Peroxide.
  • リンショウ ゲンバ カラ ミタ カサンカ シシツ ソクテイ ノ イギ

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Lipid peroxidation mediated by free radicals is believed to be one of the important causes of membrane and cell damage. So the measurement of lipid peroxide is useful to know the mechanism of oxidation in various diseases. For example, we have been investigated that the lipid peroxide caused by the stress in gastric mucosa is suggested to cause gastric lesions. The same findings are seen in other diseases like as diabetes mellitus, liver diseases, and so on. The analysis of lipidperoxide is usually done by thiobarbituric acid (TBA) or MCDP method clinically. We have also established the analytic system of lipid hydroperoxide by high performance liquid chromatography (HPLC) using chemiluminescense which could separate unsaturated fatty acid and lipid hydroperoxide simultaneously. The water immersion restraint stress of rat induced significant rise of anti-oxidant capability as an adaptive reaction. So the measurement of anti-oxidant capability is also an important way to know the pathophysiology of diseases induced by oxidant stress.

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  • 日本油化学会誌

    日本油化学会誌 46 (10), 1159-1166, 1997

    公益社団法人 日本油化学会

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