The Forefront of Lipid Nutrition.

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  • 脂質栄養学の最前線　　脂質栄養と動脈硬化
  • シシツ エイヨウガク ノ サイゼンセン シシツ エイヨウ ト ドウミャク コウ
  • 脂質栄養と動脈硬化

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Abstract

The mortality of heart disease in Japan remains very low compared with that in the United States, France and the United Kingdom.<BR>Genetic factors presumably play a large part in this difference but lifestyle, together with recent efforts in understanding dietary contributions through clinical nutrition research also plays an important role.<BR>Many studies have confirmed that while saturated fatty acids increase serum cholesterol levels, polyunsaturated fatty acids, especially n-6 fatty acids decrease serum cholesterol levels.<BR>However, the biological down-side of increasing n-6 fatty acid levels is an increase in sus-ceptibility of LDL to oxidation : when associated with oxidative changes to PUFA-rich LDL, the result is that an increased atherogenesity of this lipoprotein intake is an increased susceptibility of LDL to oxidation.<BR>With this in mind, an analysis of the current Japanese fat intake suggests that the present levels of consumption regarding both quantity and quality of fat are ideal for preventing the current low levels of atherosclerosis in this country.

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