Formation of W/O Type Microemulsions in Biocompatible Surfactant Systems.

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  • TAOKA Hidemi
    Division of Artificial Environments Systems, Graduate School of Engineering, Yokohama National University
  • OGAWA Etsuko
    Division of Artificial Environments Systems, Graduate School of Engineering, Yokohama National University
  • TAKAHASHI Masao
    Chugai Pharmaceutical Co., Ltd. Institute for Advanced Skin Research Inc.
  • KUNIEDA Hironobu
    Division of Artificial Environments Systems, Graduate School of Engineering, Yokohama National University

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Other Title
  • 生体適合性界面活性剤系におけるＷ／Ｏ型マイクロエマルションの形成
  • セイタイ テキゴウセイ カイメン カッセイザイケイ ニ オケル WOガタ マイ

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Abstract

W/O-type microemulsions are formed in Ringer's solution/sodium taurochorate (NaTC) /sorbitan laurate (SL-10) /isopropyl myristate (IPM) system. The solubilization of water becomes maximum when the hydrophile-lipophile features of the mixed surfactant are optimal in a given oil/water system. Polyoxyethylene hydrogenated caster oil (HCO-10) is slightly hydrophilic and its solubilization is reduced when mixed with NaTC, with grycerol tris (2-ethyl) hexanoate (TEH) or IPM as an oil. When HCO-10 is combined with more lipophilic cosurfactant, SL-10, glycerol 1-oleate (MGO), solubilization increases. HLB of HCO-10 alone is optimal in a water/IPM system and the solubilization of water is reduced whenever a lipophilic or hydrophilic surfactant is present. Examination was also made of the effects of temperature and the types of oils (IPM, TEH) on the formation of microemulsions.

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