γ線照射による機能性混合脂質リポソームの調製とその性質

• 細井 文雄

  日本原子力研究所高崎研究所

• 大道 英樹

  日本原子力研究所高崎研究所

• 赤間 和博

  日本油脂 (株) 筑波研究所

• 粟井 浩二

  日本油脂 (株) 筑波研究所

• 矢野 嘉宏

  日本油脂 (株) 筑波研究所

• 中野 善郎

  日本油脂 (株) 筑波研究所

書誌事項

タイトル別名

• Preparation and Properties of Functional Mixed-Lipid Liposomes by γ-Ray Irradiation
• Preparation and Properties of Functiona

抄録

The feature of mixed-lipid liposomes such as polymerization and polymerized liposomes stability were investigated to find means for producing red cells containing hemoglobin inside the liposomes. The surface pressure-area isotherm values of the mixed-lipid monolayer indicated 1-stearoyl-2- (2, 4-octadecadienoyl) -glycero-3-phosphocholine (SOPC) to be immiscible in cholesterol (Chol) and stearic acid (SA), and each component to contain separate domains in the bilayer membrane of liposomes. Radiation induced polymerization of mixed-SOPC liposomes was carried out using γ-rays from⁶⁰ Co at 4°C to stabilize lipid bilayers. The polymer yield increased significantly by adding Chol and SA to SOPC. The rate of polymerization of SOPC Liposomes increased linearly with increasing of dose rate. The molecular weight of the polymer decreased with an increase in irradiation time. Irradiated SOPC/Chol/SA liposome vesicle size was affected by freeze-thawing. The vesicle size did not change when SOPC/Chol/SA was present in the system due to the addition of immiscible saturated 1, 2-dipalmi-toyl-glycero-3-phosphocholine (DPPC).

収録刊行物

• 日本油化学会誌

  日本油化学会誌 47 (1), 31-40,85, 1998

  公益社団法人 日本油化学会

キーワード

• γ-irradiation
• polymerization
• phospholipid
• liposomes
• artificial red blood cells

詳細情報

• CRID: 1390282679068207488
• NII論文ID: 130001015638
• NII論文ID: 10002274933
• NII書誌ID: AN10512582
• DOI: 10.5650/jos1996.47.31
• ISSN: 18841996
• ISSN: 13418327
• NDL書誌ID: 4380645
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4380645
• Web Site: https://www.jstage.jst.go.jp/article/jos1996/47/1/47_1_31/_pdf
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