ジアシルグリセリンの長期摂取によるヒトの体脂肪代謝に及ぼす効果

• 渡邊 浩幸

  花王株式会社生物科学研究所

• 長尾 知紀

  花王株式会社生物科学研究所

• 後藤 直宏

  花王株式会社生物科学研究所

• 福島 陽子

  花王株式会社生物科学研究所

• 鬼沢 孝司

  花王株式会社生物科学研究所

• 田口 浩之

  花王株式会社生物科学研究所

• 大町 登志子

  花王株式会社生物科学研究所

• 安川 拓次

  花王株式会社生物科学研究所

• 内藤 幸雄

  花王株式会社生物科学研究所

• 島崎 弘幸

  帝京大学医学部第一生化学教室

• 板倉 弘重

  国立健康・栄養研究所臨床栄養部

書誌事項

タイトル別名

• Long-Term Effects of Dietary Diacylglycerols on Body Fat Metabolism in Man
• ジアシルグリセリン ノ チョウキ セッシュ ニヨル ヒト ノ タイシボウ タイ

抄録

This study was conducted to examine the long-term effects of dietary diacylglycerols (DG) on body fat in man. The fatty acid composition of DG used in this study was similar to that of triacylglycerols (TG). Healthy male subjects (27-49 years) were supplied their usual diet with 50g TG (15g for breakfast, 15g for lunch and 20g for dinner) a day. After a 4-week TG diet period, the subjects were divided into two groups to be supplied their usual breakfast with either 10g lipids of DG or TG. Every 4 weeks, the subjects visited the clinic for blood sampling, and had abdominal fats and liver fat determined by computed tomography (CT). In the DG diet group, body weight, body mass index and waist hip ratio decreased significantly after 12 week ingestion compared to the TG diet group. Fat in the abdominal region at the end of the DG diet decreased more than the end of the TG diet. The results for the liver CT/spleen CT ratio which is an indicator of liver fat content showed that fat in the liver had decreased significantly 8 and 12 week after ingestion in the DG diet group. A decreasing effect of DG on the amount of lipid of the liver in the DG diet group was clearly observed in the subjects with a greater reduction in free fatty acid in the serum. On the other hand, the amount of ketone body in the DG diet group was inclined to be higher than that in the TG diet group. Glucose and insulin in the serum increased significantly after the TG diet, but it did not increased during the period of examination in the DG diet group. These results showed that the DG diet improved insulin sensitivity and reduced visceral and liver fat by increasing β-oxidation in the liver. It can be considered that DG is an ideal source of energy, assuring less fat accumulation by decreasing serum insulin and fatty acids compared to TG.

収録刊行物

• 日本油化学会誌

  日本油化学会誌 47 (4), 369-376,388, 1998

  公益社団法人 日本油化学会

キーワード

• diacylglycerol
• triacylglycerol
• human
• dietary lipid
• body fat
• metabolism

詳細情報

• CRID: 1390001204091507456
• NII論文ID: 10002275483
• NII書誌ID: AN10512582
• DOI: 10.5650/jos1996.47.369
• ISSN: 18841996
• ISSN: 13418327
• ISSN: http://id.crossref.org/issn/13458957
• NDL書誌ID: 4459385
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4459385
• Web Site: https://www.jstage.jst.go.jp/article/jos1996/47/4/47_4_369/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1998173679
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
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