Conformational Changes in the β-Glycyrrhetinic Acid Skeleton. Microenvironmental Effects of Solvent Polarity and Amphiphilic Effects of the Polyethylene Glycol Side Chain.

• TAMAGAKI Seizo

  Department of Bioapplied Chemistry, Faculty of Engineering, Osaka City University

• TOYOSHIMA Toshinobu

  Department of Bioapplied Chemistry, Faculty of Engineering, Osaka City University

Bibliographic Information

Other Title

• 抗炎症薬β-グリシルレチン酸骨格のコンホメーション変化-溶媒極性のミクロ環境効果とポリエチレングリコール側鎖の両親媒性効果-
• コウ エンショウヤク ベータグリシルレチンサン コッカク ノ コンホメーショ

Abstract

The circular dichroism (CD) of the inflammatory drug β-glycyrrhetinic acid (β-GA) with tripenoidal skelton showed considerable variation in the CD amplitude with change in solvent polarity, due primarily to the high conformational flexibility of the enone portion of the β-GA skeleton. No such variation was observed for α-GA. β-GA with a polyethylene side chain exhibited enhanced selectivity toward Li⁺ over Na⁺ or K⁺.

Journal

• Journal of Japan Oil Chemists' Society

  Journal of Japan Oil Chemists' Society 47 (8), 765-772,789, 1998

  Japan Oil Chemists' Society

Keywords

• conformational changes
• β-glycyrrhetinic acid
• solvent polarity
• polyethylene glycol side chain

Details

• CRID: 1390001204091841152
• NII Article ID: 10002276232
• NII Book ID: AN10512582
• DOI: 10.5650/jos1996.47.765
• ISSN: 18841996
• ISSN: 13418327
• ISSN: http://id.crossref.org/issn/13458957
• NDL BIB ID: 4546061
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4546061
• Web Site: https://www.jstage.jst.go.jp/article/jos1996/47/8/47_8_765/_pdf
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed