Roles of Lipid Mediators in Cytokine-induced Apoptosis

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  • TSUJIMOTO Masafumi
    Laboratory of Cellular Biochemistry, The Institute of Physical and Chemical Research (RIKEN)

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  • アポトーシスにおける脂質メディエーターの役割
  • アポトーシス ニ オケル シシツ メディエーター ノ ヤクワリ

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Abstract

There is increasing evidence that lipid mediators such as arachidonic acid and ceramide are importantly involved in cytokine-induced apoptosis. An L929 subclone, selected for its resistance to TNF cytotoxicity, was inadequate in cPLA2 activity. The expression of cloned cPLA2 cDNA in resistant cells caused the sensitivity of cells to increase toward TNF. TNF caused ceramide to accummulate in sensitive but not resistant cells. Ceramide treatment eliminated resistance to TNF and led to cell death in resistant cells. The significance of and possible link between mediators in cytokine-induced apoptosis are thus demonstrated by the present results. The functions of lipid mediators in the cytokine-induced apoptosis are discussed with special attention directed to the interrelationships of these meditors to other mediators reported to date.

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