Molecular Interactions between Surface-Modified Lipid Bilayers and a Water-Soluble Polymer

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  • YOSHIDA Ayumi
    Faculty of Science and Technology, Science University of Tokyo
  • HASHIZAKI Kaname
    Faculty of Science and Technology, Science University of Tokyo
  • El-MAHDY Mona
    Faculty of Science and Technology, Science University of Tokyo
  • YAMAUCHI Hitoshi
    Faculty of Science and Technology, Science University of Tokyo
  • SAKAI Hideki
    Faculty of Science and Technology, Science University of Tokyo Institute of Colloid and Interface Science, Science University of Tokyo
  • YOKOYAMA Shoko
    Kyoritsu College of Pharmacy
  • ABE Masahiko
    Faculty of Science and Technology, Science University of Tokyo Institute of Colloid and Interface Science, Science University of Tokyo

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  • 表面修飾した脂質二分子膜と水溶性高分子との相互作用
  • Molecular Interactions between Surface-

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Abstract

Molecular interactions between liposomes, the surface of which was modified by adding 6mol% of poly (ethylene glycol) -lipid (termed PEG-liposomes), and chondroitin sulfate C (CS) as a water-soluble polymer have been investigated in terms of the particle size, zeta-potential, microviscosity, micropolarity and permeability of PEG-liposomes. The particle size and the absolute value of the zeta-potential of PEG-liposomes were found to increase with increasing concentration of CS added. The permeability of PEG-liposomes was decreased by the addition of CS. These were considered to be caused by the complexation between CS and liposomal PEG-chains and by the further adsorption of CS onto CS-PEG-liposomes. The effect of CS on the microviscosity of PEG-liposomes was dependent on the concentration of CS. The packing state of PEG-liposomal lipid bilayer became most rigid by the addition of ca. 4mg mL-1 of CS.

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