健常人における<SUP>111</SUP>In-DTPA-IgGの生体内分布と動態

• 中村 佳代子

  慶應義塾大学医学部放射線科

• 三宮 敏和

  慶應義塾大学医学部放射線科

• 清水 正三

  慶應義塾大学医学部放射線科

• 橋本 順

  慶應義塾大学医学部放射線科

• 久保 敦司

  慶應義塾大学医学部放射線科

書誌事項

タイトル別名

• Distribution and Pharmacokinetics of 111In-DTPA-IgG in Healthy Human Subjects.
• 健常人における111In-DTPA-IgGの生体内分布と動態〔英文〕
• ケンジョウジン ニ オケル 111In DTPA IgG ノ セイタイナイ ブ

抄録

We assessed the biodistribution of ¹¹¹In-DTPA-IgG administered to volunteers with a pharmacokinetic analysis. Volunteers were injected with 80MBq of ¹¹¹In-DTPA-IgG. ¹¹¹In uptakes decreased with time in all organs except in liver and bone marrow. At 70 h after injection, ¹¹¹In uptakes in the intestine was 1.0% ID, suggesting that ¹¹¹In-DTPA-IgG would be feasible to detect inflammation located in the abdomen. Analysis of plasma by size-exclusion HPLC showed mainly one radioactivity peak of labeled IgG, suggesting that ¹¹¹In-DTPA-IgG was stable in the blood. The blood clearance was fitted to a two-compartment equation with half-lives of 6.6±1.6 h and 35.5±2.0 h for T_1/2α and T_1/2β, respectively. Total urinary excretion averaged 12.0±0.9% dose/72h, suggesting that ¹¹¹In-DTPA-IgG may be excreted slowly through the urinary system.

収録刊行物

• ＲＡＤＩＯＩＳＯＴＯＰＥＳ

  ＲＡＤＩＯＩＳＯＴＯＰＥＳ 44 (5), 303-309, 1995

  公益社団法人 日本アイソトープ協会

キーワード

• <SUP>111</SUP>In-DTPA-IgG
• distribution
• pharmacokinetics
• human subject

詳細情報

• CRID: 1390001204153321856
• NII論文ID: 130004382788
• NII論文ID: 10002390710
• NII書誌ID: AN00351589
• DOI: 10.3769/radioisotopes.44.303
• ISSN: 18844111
• ISSN: 00338303
• NDL書誌ID: 3619000
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I3619000
• Web Site: http://www.jstage.jst.go.jp/article/radioisotopes1952/44/5/44_5_303/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1996123146
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可