Contribution of Substituents to the Distribution Coefficient of N-Benzoyl-N-phenylhydroxylamine Derivatives

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著者

    • UTO Masayuki
    • Department of Material Science, Kitami Institute of Technology

抄録

The distribution coefficient (<i>K</i><sub>D</sub>) for twenty kinds of <i>N</i>-benzoyl-<i>N</i>-phenylhydroxylamine (BPHA) derivatives between chloroform or benzene and the aqueous phase was determined. A linear correlation was obtained between log <i>K</i><sub>D</sub> and the number of carbon atoms containing substituent groups for a series of alkyloxy derivatives. However, the data for those having a series of alkyloxy groups, and others having a straight or branched alkyl chain, fall on two independent lines in plots of log <i>K</i><sub>D</sub> vs. the van der Waals volume of the BPHA derivatives. From these results, the empirical contribution values (π<sub>x</sub>), defined asπ<sub>x</sub>=log <i>K</i><sub>D</sub>(X)-log <i>K</i><sub>D</sub>(H) {<i>K</i><sub>D</sub>(H) is the distribution coefficient of a parent compound and <i>K</i><sub>D</sub>(X) that of a derivative}, of the functional group to the distribution coefficient (log <i>K</i><sub>D</sub>), were as follows: 0.54 in a chloroform/ water system and 0.49 in a benzene/water system for the methyl and methylene groups, 0.30 in a chloroform/water system and 0.27 in a benzene/water system for the methoxy group, and -0.23 in a chloroform/water system and -0.12 in a benzene/water system for the nitro group, respectively. The utility of the contribution values (π<sub>x</sub>) for the methyl, methylene, methoxy and nitro groups was verified for estimating the distribution coefficient (<i>K</i><sub>D</sub>) of the BPHA derivatives.

収録刊行物

  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry  

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 11(5), 723-728, 1995-10-10 

    The Japan Society for Analytical Chemistry

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各種コード

  • NII論文ID(NAID)
    10002406387
  • NII書誌ID(NCID)
    AA10500785
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09106340
  • データ提供元
    CJP書誌  J-STAGE 
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