A Derivatizing Reagent-Kit Using a Single Coumarin Fluorophore.

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  • Derivatizing Reagent-Kit Using a Single

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Abstract

6, 7-Dimethoxycoumarins having various reactive groups such as bromoacetyl-, hydrazinocarbonyl- and chlorocarbonyl- groups at 3-position on coumarin ring were synthesized for the construction of a fluorescent derivatizing reagent-kit for carboxylic acids, aldehyde/ketone, alcohol, phenol and amines. These reagents were evaluated from their reactivities with model compounds and fluorescent characteristics of products obtained. Of the reagents, 3-bromoacetyl- and 3- chlorocarbonyl-6, 7-dimethoxycoumarins were found to afford highly fluorescent products with above 0.8 in quantum yields for carboxylic acids, alcohol and aliphatic amines. It was found that the construction of reagent-kit by using a single fluorophore selected after consideration of its emission mechanism can be significant and useful as an approach for the efficient reagent development.

Journal

  • Analytical Sciences

    Analytical Sciences 13 (5), 753-756, 1997

    The Japan Society for Analytical Chemistry

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