An Optic-Fiber Sensor for Metronidazole Based on the Fluorescence Quenching of a Copolymer Bound Flavone Derivative.

DOI PDF Web Site Web Site Web Site 参考文献32件
  • LIU Wanhui
    College of Chemistry and Chemical Engineering, Hunan University Analytical Center, Yantai University
  • WANG Ying
    College of Chemistry and Chemical Engineering, Hunan University
  • TANG Jianghong
    College of Chemistry and Chemical Engineering, Hunan University
  • SHEN Guoli
    College of Chemistry and Chemical Engineering, Hunan University
  • YU Ruqin
    College of Chemistry and Chemical Engineering, Hunan University

書誌事項

タイトル別名
  • Optic-Fiber Sensor for Metronidazole Ba

この論文をさがす

抄録

A new optic-fiber sensor for metronidazole (1-(2-hydroxyethyl)-2-methyl-5-nitromidazole) has been fabricated with a fluorescent copolymer prepared from 3-hydroxy-4′-N,N-dimethylaminoflavone methacrylate, methyl methacrylate, and butyl acrylate (PFMB). The sensing is based on the quenching of the fluorescence of a PFMB membrane by metronidazole. An orthogonal-experimental design was used for the membrane composition optimization. The present sensor responds linearly to metronidazole in the concentration range of 3.00×10-5 mol l-1 to 3.00×10-3 mol l-1 with a detection limit of 1.00×10-5 mol l-1. The response is on the order of 30 s. The lifetime is enhanced by covalently immobilizing the flavone derivative to the membrane, which hinders leaching of the dye from the membrane. With the described sensor, good reproducibility and reversibility have been realized. The sensor has also shown good selectivity over common inorganic anions and cations, and some pharmaceuticals. It can be used for the direct determination of metronidazole in commercial pharmaceutical preparations; the obtained results were in agreement with those obtained by a pharmacopoeia method.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 14 (3), 547-551, 1998

    社団法人 日本分析化学会

参考文献 (32)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ