Microfabricated On-Line Sensor for Continuous Monitoring of L-Glutamate

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抄録

An on-line sensor was developed by using a micro-machining technique for the continuous measurement of extracellular glutamate. The sensor was made by bonding two glass plates together. One of the plates has a rectangular flow channel which is connected to both a sampling and an outlet capillary. The other has a carbon film-based electrochemical cell, which consists of an enzyme-modified electrode surrounded by polymer film to form a thin-layer-channel flow cell. The sensor has a high analyte conversion efficiency due to the cell structure. As a result, we obtained a low detection limit of 44 nM (S/N=3). The cathodic current started to increase about 10 s after sample introduction at a flow rate of 2 μl/min due to its small inner volume. Using the sensor, we can monitor the extracellular <font size=-2>L</font>-glutamate increase caused by stimulating it with KCl and γ-aminobutyric acid (GABA) by locating the sampling capillary very close to the cell.

収録刊行物

  • Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 14(5), 947-953, 1998-10-10

    社団法人 日本分析化学会

参考文献:  42件中 1-42件 を表示

  • <no title>

    BLISS T. V. P.

    J. Physiol. 377, 391, 1986

    被引用文献1件

  • <no title>

    ITO M.

    J. Physiol. 324, 113, 1982

    被引用文献1件

  • <no title>

    ITO M.

    Neuroscience 3, 531, 1986

    被引用文献1件

  • <no title>

    BENVENISTE H.

    J. Neurochem. 43, 1369, 1984

    被引用文献2件

  • <no title>

    WAHL F.

    J. Neurochem. 63, 1003, 1994

    被引用文献1件

  • <no title>

    KISSINGER P. T.

    Microdialysis in neurosciences, 103-115, 1991

    被引用文献1件

  • <no title>

    ZHOU S. Y.

    Anal. Chem. 67, 594, 1995

    被引用文献2件

  • <no title>

    LADA M. W.

    Anal. Chem. 69, 4560, 1997

    被引用文献4件

  • <no title>

    KUHR W. G.

    Anal. Chem. 65, 617, 1993

    被引用文献3件

  • <no title>

    SCHUBERT F.

    Anal. Lett. 19, 1273, 1986

    被引用文献2件

  • <no title>

    NIKOLEIS D. P.

    Analyst[London] 112, 763, 1987

    被引用文献1件

  • <no title>

    HU Y.

    Brain Res. 659, 117, 1994

    被引用文献8件

  • <no title>

    TAMIYA E.

    Sens. Mater. 7, 249, 1995

    被引用文献3件

  • <no title>

    TAMIYA E.

    Sensors Actuators, B 10, 179, 1993

    被引用文献1件

  • <no title>

    COSNIER S.

    Anal. Chem. 69, 968, 1997

    被引用文献4件

  • <no title>

    ALBERY W. J.

    J. Chem. Soc., Chem. Commun. 1992, 900

    被引用文献2件

  • <no title>

    BERNERS M. O. M.

    Anal. Chem. 66, 2017, 1994

    被引用文献4件

  • <no title>

    ZILKHA E.

    J. Neurosci. Meth. 60, 1, 1995

    被引用文献1件

  • <no title>

    ZILKHA E.

    Anal. Lett. 27, 453, 1994

    被引用文献6件

  • <no title>

    NIWA O.

    Anal. Chem. 68, 1865, 1996

    被引用文献16件

  • <no title>

    ROBERT F.

    J. Neyrisci. Meth. 74, 65, 1997

    被引用文献1件

  • <no title>

    NIWA O.

    Biosens. Bioelectron. 12, 311, 1997

    被引用文献5件

  • <no title>

    TORIMITSU K.

    NeuroReport 8, 1353, 1997

    被引用文献6件

  • <no title>

    MANZ A.

    Sensors Actuators B1, 249, 1990

    被引用文献1件

  • <no title>

    MANZ A.

    J. Chrinatogr. 593, 253, 1992

    被引用文献1件

  • <no title>

    GAVIN P. F.

    J. Am. Chem. Soc. 118, 8932, 1996

    被引用文献2件

  • <no title>

    JACOBSON S. C.

    Anal. Chem. 66, 1114, 1994

    被引用文献5件

  • <no title>

    HARRISON D. J.

    Anal. Chem. 64, 1926, 1992

    被引用文献18件

  • <no title>

    WOOLLEY A. T.

    Anal. Chem. 68, 4081, 1996

    被引用文献8件

  • <no title>

    van der SCHOOT B. H.

    Sensors Actuators B6, 57, 1992

    被引用文献1件

  • <no title>

    MURAKAMI Y.

    Anal. Chem. 65, 2731, 1993

    被引用文献5件

  • <no title>

    DEMPSEY E.

    Anal. Chim. Acta 346, 241, 1997

    被引用文献1件

  • <no title>

    MOSER I.

    Biosens. Bioelectron. 10, 527, 1995

    被引用文献2件

  • <no title>

    YANG L.

    Anal. Chem. 67, 1326, 1995

    被引用文献4件

  • <no title>

    TABEI H.

    J. Electroanal. Chem. 334, 25, 1992

    被引用文献3件

  • <no title>

    NIWA O.

    Anal. Chem. 66, 285, 1994

    被引用文献4件

  • <no title>

    NIWA O.

    Anal. Chem. 70, 89, 1998

    被引用文献4件

  • <no title>

    NIWA O.

    Anal. Chem. 70, 1126, 1998

    被引用文献5件

  • <no title>

    BLISS T. V. P.

    Nature 361, 31-39, 1993

    DOI 被引用文献147件

  • <no title>

    SHOJI S.

    Sensors and Actuators 14(2), 101, 1988

    DOI 被引用文献13件

  • <no title>

    SIBBALD A.

    Anal. Chim. Acta 159, 47, 1984

    DOI 被引用文献1件

  • <no title>

    VREEKE M. S.

    Anal. Chem. 64, 3084, 1992

    DOI 被引用文献8件

各種コード

  • NII論文ID(NAID)
    10002417312
  • NII書誌ID(NCID)
    AA10500785
  • 本文言語コード
    ENG
  • 資料種別
    ART
  • ISSN
    09106340
  • NDL 記事登録ID
    4576993
  • NDL 雑誌分類
    ZP4(科学技術--化学・化学工業--分析化学)
  • NDL 請求記号
    Z54-F482
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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