Determination of Benzydamine Hydrochloride in Serum and Urine by Using a Benzydamine Ion-Selective Piezoelectric Sensor.

LI Weifeng, SU Xiaoli, ZHANG Hong, NIE Lihua, YAO Shuozhuo

doi:10.2116/analsci.14.955

Determination of Benzydamine Hydrochloride in Serum and Urine by Using a Benzydamine Ion-Selective Piezoelectric Sensor.

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LI Weifeng

College of Chemistry and Chemical Engineering, Hunan University
SU Xiaoli

College of Chemistry and Chemical Engineering, Hunan University
ZHANG Hong

College of Chemistry and Chemical Engineering, Hunan University
NIE Lihua

College of Chemistry and Chemical Engineering, Hunan University
YAO Shuozhuo

College of Chemistry and Chemical Engineering, Hunan University

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タイトル別名

Determination of Benzydamine Hydrochlor

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An ion-selective piezoelectric sensor (ISP) was developed for the rapid determination of benzydamine hydrochloride in serum and urine. The ISP device was fabricated by coating a PVC membrane containing benzydamine phosphotungstate on one electrode of a thickness-shear mode piezoelectric quartz crystal. The selective adsorption of benzydamine ion across the membrane caused a decrease in the oscillating frequency; also the logarithm of the frequency shift has a linear relation to the logarithm of the concentration of benzydamine over the ranges 2×10^-7 - 8×10^-3 M with a detection limit of 2.0×10^-7 M at pH 7.0. Influencing factors were investigated and optimized. The results for real samples obtained by the proposed method were in agreement with those by the conventional non-aqueous titrimetric method.