Biological Activities of a Novel Lectin Derived from Silkworm Faeces:Characteristic Changes of Mouse Peritoneal Macrophages by the Lectin.

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  • Hirayama Etsuko
    Institutes of Molecular and Cellular Biology for Pharmaceutical Sciences, Kyoto Pharmaceutical University
  • Maekawa Hisayuki
    Institutes of Molecular and Cellular Biology for Pharmaceutical Sciences, Kyoto Pharmaceutical University
  • Hiraki Akihiro
    Institutes of Molecular and Cellular Biology for Pharmaceutical Sciences, Kyoto Pharmaceutical University
  • Kim Jeman
    Institutes of Molecular and Cellular Biology for Pharmaceutical Sciences, Kyoto Pharmaceutical University

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  • Biological Activities of a Novel Lectin Derived from

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A novel lectin derived from silkworm faeces, named NUE, activates phagocytosis of mouse peritoneal macrophages (9). At this time, significant morphological changes of the cells take place. NUE-treated macrophages formed projection-like neurocytes within 12 hr of treatment, and appeared somewhat flat in shape with the activation of cell growth. Associated with the morphological changes, actin was organized in dot-like structures corresponding to cell-substratum contact sites in NUE-treated macrophages. Vinculin, a cytoskeletal protein involved in microfilament-membrane interaction, formed doughnut-like rings matching the actin-dots, called "podosomes". Furthermore, observation by interference reflection microscopy showed that NUE-treated macrophages adhered more strongly to the substratum at local areas. According to these changes, more proteins associated with cell-substratum contact sites became to detergent-resistant. It was shown that NUE changed adhesive form of mouse peritoneal macrophages structurally and qualitatively.

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