Transient Up-regulation of Myotonic Dystrophy Protein Kinase-binding Protein, MKBP, and HSP27 in the Neonatal Myocardium.
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- Mohammed Abu Shama Kazi
- Department of Legal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
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- Suzuki Atsushi
- Department of Molecular Biology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, Kanagawa, Japan
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- Harada Kazuki
- Department of Legal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
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- Fujitani Noboru
- Department of Legal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
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- Kimura Hiroshi
- Department of Legal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
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- Ohno Shigeo
- Department of Molecular Biology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, Kanagawa, Japan
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- Yoshida Ken-ichi
- Department of Legal Medicine, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan
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抄録
Myotonic dystrophy protein kinase (DMPK)-binding protein, MKBP, has high homology with a small heat shock protein, HSP27. Western blotting analyses showed that MKBP level in rat heart rapidly increased, with a sharp peak at one week after birth (3-fold the level at the fetus), but that it rapidly decreased (1/10 of peak value at 13 weeks). Human myocardium also showed similar age-dependency. Similar but small increase of HSP27 was observed in the neonatal rat myocardium, but not in constitutive and inducible forms of HSP70. Immunofluorescence analysis localized MKBP at the Z lines and intercalated discs in the rat myocardium. MKBP may protect actin cytoskeleton or other proteins of heart muscle against oxidative stress in the neonate.
収録刊行物
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- Cell Structure and Function
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Cell Structure and Function 24 (1), 1-4, 1999
日本細胞生物学会
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詳細情報 詳細情報について
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- CRID
- 1390282679671488896
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- NII論文ID
- 130004137281
- 10002420491
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- NII書誌ID
- AA0060007X
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- DOI
- 10.1247/csf.24.1
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- COI
- 1:CAS:528:DyaK1MXisVagtLk%3D
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- ISSN
- 13473700
- 03867196
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- NDL書誌ID
- 4685308
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- PubMed
- 10355872
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可