Geranylgeranylacetone Induces Apoptosis in HL-60 Cells.
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- Okada Shohei
- Department of Cell Chemistry, Institute of Molecular and Cell Biology, Okayama University Medical School, Okayama 700-8558, Japan
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- Yabuki Munehisa
- Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710-8522, Japan
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- Kanno Tomoko
- Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710-8522, Japan
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- Hamazaki Keisuke
- Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710-8522, Japan
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- Yoshioka Tamotsu
- Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710-8522, Japan
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- Yasuda Tatsuji
- Department of Cell Chemistry, Institute of Molecular and Cell Biology, Okayama University Medical School, Okayama 700-8558, Japan
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- A. Horton Alan
- School of Biochemistry, University of Birmingham, Edgebaston, Birmingham B15 2TT, United Kingdom
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- Utsumi Kozo
- Institute of Medical Science, Kurashiki Medical Center, Kurashiki 710-8522, Japan
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抄録
Geranylgeranylacetone (GGA) induces apoptosis in human leukemia HL-60 cells in a dose-and time-dependent manner. This effect was completely prevented by the pan-caspase inhibitor z-Val-Ala-Asp(OMe) fluoromethylketone, thereby implicating the caspase cascade in the process. Prior to DNA fragmentation, GGA treatment markedly activated caspase-3(-like) proteases, which might be responsible for the observed apoptosis. In addition, GGA treatment interfered with the processing and membrane localization of Rap1 and Ras, and these changes may be a result of apoptosis. Moreover, nitric oxide donors significantly accentuated the GGA-induced apoptosis, suggesting that the apoptotic pathway induced by GGA might be regulated by a redox-sensitive mechanism. Taken together, these data suggest that the isoprenoid, GGA, is an effective inducer of apoptotic cell death in HL-60 cells.
収録刊行物
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- Cell Structure and Function
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Cell Structure and Function 24 (3), 161-168, 1999
日本細胞生物学会
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詳細情報
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- CRID
- 1390282679673254400
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- NII論文ID
- 10002421098
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- NII書誌ID
- AA0060007X
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- COI
- 1:CAS:528:DyaK1MXlsFKgsrw%3D
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- ISSN
- 13473700
- 03867196
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- NDL書誌ID
- 4821092
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- PubMed
- 10462178
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可