DNA-protein Interactions by Transcription Factors.

  • HAKOSHIMA Toshio
    Department of Molecular Biology, Nara Institute of Science and Technology

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  • 転写因子におけるDNA‐蛋白質相互作用
  • テンシャ インシ ニ オケル DNA タンパクシツ ソウゴ サヨウ

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Abstract

The diversity of transcription factor-DNA complexes reviewed in this paper marks the extent of discovery since the first transcription factor-DNA co-crystal structures appeared less than ten years ago. The DNA-binding domains of transcription factors were classified into families, many of which have been identified by comparative amino acid sequence analysis. The three-dimensional views of their respective families revealed new designs as well as unanticipated similarities to older ones. Several hoped-for simplicities in their DNA-recognition mechanism have proved illusory, but other unexpected regularities have emerged.

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