大腸菌由来DNA修復酵素3- メチルアデニンDNAグリコシラーゼの構造と機能 Structural Basis for the Recognition and removal of damaged bases from DNA by a DNA Repair Enzyme, 3-Methyladenine DNA glycosylase from Escherichia coli
Escherichia coli 3-methyladenine DNA glycosylase II is a DNA repair enzyme that removes numerous alkylated bases from DNA. The three-dimensional structure, mutagenesis and model building studies suggest that the active site is located in a cleft between the two helical domains and that the enzyme flips the target base out of the DNA duplex into the active-site cleft. The structural similarity among a variety of DNA glycosylases shows the existence of a DNA glycosylase family, whose members recognize diverse sets of substrates.
日本結晶学会誌 39(4), 303-308, 1997-08-28
The Crystallographic Society of Japan